UNLABELLED: Copper-62-pyruvaldehyde bis(N4-methylthiosemicarbazone) copper II (62Cu-PTSM) has been proposed as a generator-produced positron-emitting tracer for perfusion imaging. To evaluate the characteristics of 62Cu-PTSM as a cerebral perfusion tracer, brain PET images of 62Cu-PTSM were compared with cerebral blood flow (CBF). METHODS: Following an intravenous injection of 62Cu-PTSM, a serial dynamic PET scan was performed for 10 min with arterial sampling in 10 subjects. CBF was measured by 15O-labeled water before the 62Cu-PTSM study. RESULTS: Dynamic PET scan with octanol-extracted arterial input function indicated the presence of significant back-diffusion of 62Cu-PTSM from the brain within 3 min after injection, followed by stable activity from 3 to 10 min. Comparison with 15O-water PET demonstrated less contrast between high- and low-flow regions in 62Cu-PTSM image and a nonlinear relationship of flow and 62Cu-PTSM uptake, which suggests the underestimation of CBF in high-flow regions due to the existence of back-diffusion. CONCLUSION: Although 62Cu-PTSM can be used widely for evaluation of brain perfusion with PET, kinetic analysis and correction may be needed to quantify regional CBF.
UNLABELLED: Copper-62-pyruvaldehyde bis(N4-methylthiosemicarbazone)copper II (62Cu-PTSM) has been proposed as a generator-produced positron-emitting tracer for perfusion imaging. To evaluate the characteristics of 62Cu-PTSM as a cerebral perfusion tracer, brain PET images of 62Cu-PTSM were compared with cerebral blood flow (CBF). METHODS: Following an intravenous injection of 62Cu-PTSM, a serial dynamic PET scan was performed for 10 min with arterial sampling in 10 subjects. CBF was measured by 15O-labeled water before the 62Cu-PTSM study. RESULTS: Dynamic PET scan with octanol-extracted arterial input function indicated the presence of significant back-diffusion of 62Cu-PTSM from the brain within 3 min after injection, followed by stable activity from 3 to 10 min. Comparison with 15O-water PET demonstrated less contrast between high- and low-flow regions in 62Cu-PTSM image and a nonlinear relationship of flow and 62Cu-PTSM uptake, which suggests the underestimation of CBF in high-flow regions due to the existence of back-diffusion. CONCLUSION: Although 62Cu-PTSM can be used widely for evaluation of brain perfusion with PET, kinetic analysis and correction may be needed to quantify regional CBF.
Authors: Heather Ann Williams; Simon Robinson; Peter Julyan; Jamal Zweit; David Hastings Journal: Eur J Nucl Med Mol Imaging Date: 2005-10-29 Impact factor: 9.236
Authors: Y Yonekura; K Ishizu; H Okazawa; F Tanaka; N Hattori; N Sadato; T Tsuchida; S Nishizawa; N Tamaki; T Nagamine; J Konishi; H Shibasaki Journal: Ann Nucl Med Date: 1996-05 Impact factor: 2.668
Authors: D P Holschneider; J Yang; T R Sadler; N B Galifianakis; M H Bozorgzadeh; J R Bading; P S Conti; J-M I Maarek Journal: Brain Res Date: 2008-07-19 Impact factor: 3.252
Authors: H Okazawa; Y Fujibayashi; Y Yonekura; N Tamaki; S Nishizawa; Y Magata; K Ishizu; T Tsuchida; N Sadato; J Konishi Journal: Ann Nucl Med Date: 1995-05 Impact factor: 2.668