Literature DB >> 7988873

Evidence for the location of OprM in the Pseudomonas aeruginosa outer membrane.

N Gotoh1, N Itoh, H Yamada, T Nishino.   

Abstract

OprM with a M(r) of 49 K is associated with the multidrug resistance of Pseudomonas aeruginosa. Detergent fractionation of bacterial cells has demonstrated that OprM is located in the outer membrane from which it sediments with the other major outer membrane proteins. In this study we have determined the location of OprM as the P. aeruginosa outer membrane. Western immunoblots of cell fractions, obtained by sucrose density gradient centrifugation of whole cell lysates, were probed with an OprM-specific murine polyclonal antiserum.

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Year:  1994        PMID: 7988873     DOI: 10.1111/j.1574-6968.1994.tb07185.x

Source DB:  PubMed          Journal:  FEMS Microbiol Lett        ISSN: 0378-1097            Impact factor:   2.742


  4 in total

1.  Influence of OprM expression on multiple antibiotic resistance in Pseudomonas aeruginosa.

Authors:  K K Wong; K Poole; N Gotoh; R E Hancock
Journal:  Antimicrob Agents Chemother       Date:  1997-09       Impact factor: 5.191

2.  Expression of the multidrug resistance operon mexA-mexB-oprM in Pseudomonas aeruginosa: mexR encodes a regulator of operon expression.

Authors:  K Poole; K Tetro; Q Zhao; S Neshat; D E Heinrichs; N Bianco
Journal:  Antimicrob Agents Chemother       Date:  1996-09       Impact factor: 5.191

3.  The outer membrane protein OprM of Pseudomonas aeruginosa is encoded by oprK of the mexA-mexB-oprK multidrug resistance operon.

Authors:  N Gotoh; H Tsujimoto; K Poole; J Yamagishi; T Nishino
Journal:  Antimicrob Agents Chemother       Date:  1995-11       Impact factor: 5.191

4.  Efflux pumps involved in toluene tolerance in Pseudomonas putida DOT-T1E.

Authors:  J L Ramos; E Duque; P Godoy; A Segura
Journal:  J Bacteriol       Date:  1998-07       Impact factor: 3.490

  4 in total

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