Literature DB >> 9303403

Influence of OprM expression on multiple antibiotic resistance in Pseudomonas aeruginosa.

K K Wong1, K Poole, N Gotoh, R E Hancock.   

Abstract

MexA-MexB-OprM is an efflux system in Pseudomonas aeruginosa. OprM overproduced from the cloned gene was able to complement OprM-deficient mutants but did not alter the resistance of a wild-type P. aeruginosa strain to the different antimicrobial agents tested. This suggests that OprM cannot function by itself to efflux antibiotics, including beta-lactams targeted to the periplasm.

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Year:  1997        PMID： 9303403      PMCID： PMC164054          DOI： 10.1128/AAC.41.9.2009

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  29 in total

1.  Evidence that TolC is required for functioning of the Mar/AcrAB efflux pump of Escherichia coli.

Authors:  J A Fralick
Journal:  J Bacteriol       Date:  1996-10       Impact factor: 3.490

2.  Expression of the multidrug resistance operon mexA-mexB-oprM in Pseudomonas aeruginosa: mexR encodes a regulator of operon expression.

Authors:  K Poole; K Tetro; Q Zhao; S Neshat; D E Heinrichs; N Bianco
Journal:  Antimicrob Agents Chemother       Date:  1996-09       Impact factor: 5.191

3.  Subunit structure of functional porin oligomers that form permeability channels in the other membrane of Escherichia coli.

Authors:  T Nakae; J Ishii; M Tokunaga
Journal:  J Biol Chem       Date:  1979-03-10       Impact factor: 5.157

4.  The outer membrane protein OprM of Pseudomonas aeruginosa is encoded by oprK of the mexA-mexB-oprK multidrug resistance operon.

Authors:  N Gotoh; H Tsujimoto; K Poole; J Yamagishi; T Nishino
Journal:  Antimicrob Agents Chemother       Date:  1995-11       Impact factor: 5.191

Review 5.  Bacterial multidrug resistance--emphasis on efflux mechanisms and Pseudomonas aeruginosa.

Authors:  K Poole
Journal:  J Antimicrob Chemother       Date:  1994-10       Impact factor: 5.790

6.  OprK and OprM define two genetically distinct multidrug efflux systems in Pseudomonas aeruginosa.

Authors:  M M Hamzehpour; J C Pechere; P Plesiat; T Köhler
Journal:  Antimicrob Agents Chemother       Date:  1995-11       Impact factor: 5.191

7.  Role of mexA-mexB-oprM in antibiotic efflux in Pseudomonas aeruginosa.

Authors:  X Z Li; H Nikaido; K Poole
Journal:  Antimicrob Agents Chemother       Date:  1995-09       Impact factor: 5.191

8.  Role of efflux pump(s) in intrinsic resistance of Pseudomonas aeruginosa: active efflux as a contributing factor to beta-lactam resistance.

Authors:  X Z Li; D Ma; D M Livermore; H Nikaido
Journal:  Antimicrob Agents Chemother       Date:  1994-08       Impact factor: 5.191

9.  Isolation of OprM-deficient mutants of Pseudomonas aeruginosa by transposon insertion mutagenesis: evidence of involvement in multiple antibiotic resistance.

Authors:  N Gotoh; N Itoh; H Tsujimoto; J Yamagishi; Y Oyamada; T Nishino
Journal:  FEMS Microbiol Lett       Date:  1994-10-01       Impact factor: 2.742

10.  Outer membrane proteins responsible for multiple drug resistance in Pseudomonas aeruginosa.

Authors:  N Masuda; E Sakagawa; S Ohya
Journal:  Antimicrob Agents Chemother       Date:  1995-03       Impact factor: 5.191
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  13 in total

1.  Insertion mutagenesis and membrane topology model of the Pseudomonas aeruginosa outer membrane protein OprM.

Authors:  K K Wong; R E Hancock
Journal:  J Bacteriol       Date:  2000-05       Impact factor: 3.490

2.  Evaluation of a structural model of Pseudomonas aeruginosa outer membrane protein OprM, an efflux component involved in intrinsic antibiotic resistance.

Authors:  K K Wong; F S Brinkman; R S Benz; R E Hancock
Journal:  J Bacteriol       Date:  2001-01       Impact factor: 3.490

Review 3.  Efflux-mediated resistance to fluoroquinolones in gram-negative bacteria.

Authors:  K Poole
Journal:  Antimicrob Agents Chemother       Date:  2000-09       Impact factor: 5.191

4.  Mechanism of fibroblast inflammatory responses to Pseudomonas aeruginosa elastase.

Authors:  Ali O Azghani; Kourtney Neal; Steven Idell; Rodolfo Amaro; Jason W Baker; Abdelwahab Omri; Usha R Pendurthi
Journal:  Microbiology (Reading)       Date:  2014-01-02       Impact factor: 2.777

5.  Insertion mutagenesis of the ferric pyoverdine receptor FpvA of Pseudomonas aeruginosa: identification of permissive sites and a region important for ligand binding.

Authors:  L Kilburn; K Poole; J M Meyer; S Neshat
Journal:  J Bacteriol       Date:  1998-12       Impact factor: 3.490

6.  Characterization of a Pseudomonas aeruginosa efflux pump contributing to aminoglycoside impermeability.

Authors:  S Westbrock-Wadman; D R Sherman; M J Hickey; S N Coulter; Y Q Zhu; P Warrener; L Y Nguyen; R M Shawar; K R Folger; C K Stover
Journal:  Antimicrob Agents Chemother       Date:  1999-12       Impact factor: 5.191

7.  Inner membrane efflux components are responsible for beta-lactam specificity of multidrug efflux pumps in Pseudomonas aeruginosa.

Authors:  R Srikumar; X Z Li; K Poole
Journal:  J Bacteriol       Date:  1997-12       Impact factor: 3.490

8.  Mutational analysis of the OprM outer membrane component of the MexA-MexB-OprM multidrug efflux system of Pseudomonas aeruginosa.

Authors:  X Z Li; K Poole
Journal:  J Bacteriol       Date:  2001-01       Impact factor: 3.490

9.  Multidrug efflux pump AcrAB of Salmonella typhimurium excretes only those beta-lactam antibiotics containing lipophilic side chains.

Authors:  H Nikaido; M Basina; V Nguyen; E Y Rosenberg
Journal:  J Bacteriol       Date:  1998-09       Impact factor: 3.490

10.  Contribution of outer membrane efflux protein OprM to antibiotic resistance in Pseudomonas aeruginosa independent of MexAB.

Authors:  Q Zhao; X Z Li; R Srikumar; K Poole
Journal:  Antimicrob Agents Chemother       Date:  1998-07       Impact factor: 5.191
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