Literature DB >> 7987669

Cytokines, prostaglandins and lipocortin-1 are present in the brains of scrapie-infected mice.

A E Williams1, A M van Dam, W K Man-A-Hing, F Berkenbosch, P Eikelenboom, H Fraser.   

Abstract

The presence of cytokines, prostaglandins and lipocortin-1 was investigated in terminally affected mice in two models of scrapie. There was marked induction of glial interleukin-1 beta, tumour necrosis factor alpha, prostaglandin E2, prostaglandin F2 alpha and lipocortin-1 immunoreactivity in those areas of the brain showing the characteristic vacuolation of scrapie. A comparison of these staining patterns with those of GFAP and F4/80 showed that their expression occurred predominantly in astrocytes. It is possible that cytokines play a significant role in the pathogenesis of neurodegeneration in scrapie.

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Year:  1994        PMID： 7987669     DOI： 10.1016/0006-8993(94)90480-4

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  28 in total

1.  Astrocyte-specific expression of hamster prion protein (PrP) renders PrP knockout mice susceptible to hamster scrapie.

Authors:  A J Raeber; R E Race; S Brandner; S A Priola; A Sailer; R A Bessen; L Mucke; J Manson; A Aguzzi; M B Oldstone; C Weissmann; B Chesebro
Journal:  EMBO J       Date:  1997-10-15       Impact factor: 11.598

2.  IL-1 family members as candidate genes modulating scrapie susceptibility in sheep: localization, partial characterization, and expression.

Authors:  Ane Marcos-Carcavilla; Jorge H Calvo; Carmen González; Katayoun Moazami-Goudarzi; Pascal Laurent; Maud Bertaud; Hélène Hayes; Anne E Beattie; Carmen Serrano; Jaber Lyahyai; Inmaculada Martín-Burriel; Estefânia Alves; Pilar Zaragoza; Juan J Badiola; Magdalena Serrano
Journal:  Mamm Genome       Date:  2007-01-22       Impact factor: 2.957

Review 3.  Microglia in prion diseases.

Authors:  Adriano Aguzzi; Caihong Zhu
Journal:  J Clin Invest       Date:  2017-07-17       Impact factor: 14.808

4.  Pathogenic prion protein fragment (PrP106-126) promotes human immunodeficiency virus type-1 infection in peripheral blood monocyte-derived macrophages.

Authors:  Silvia M Bacot; Gerald M Feldman; Kenneth M Yamada; Subhash Dhawan
Journal:  Virology       Date:  2015-01-09       Impact factor: 3.616

5.  Celecoxib Inhibits Prion Protein 90-231-Mediated Pro-inflammatory Responses in Microglial Cells.

Authors:  Valentina Villa; Stefano Thellung; Alessandro Corsaro; Federica Novelli; Bruno Tasso; Luca Colucci-D'Amato; Elena Gatta; Michele Tonelli; Tullio Florio
Journal:  Mol Neurobiol       Date:  2014-11-18       Impact factor: 5.590

Review 6.  Let's make microglia great again in neurodegenerative disorders.

Authors:  Marie-Victoire Guillot-Sestier; Terrence Town
Journal:  J Neural Transm (Vienna)       Date:  2017-10-12       Impact factor: 3.575

7.  Effect of PrP105-132 on the secretion of interleukin-6 and interleukin-8 from microglial cells in vitro.

Authors:  Yun-Tian Yang; Shan Jin
Journal:  Exp Ther Med       Date:  2017-11-13       Impact factor: 2.447

8.  Monocyte recruitment into the scrapie-affected brain.

Authors:  A E Williams; S Ryder; W F Blakemore
Journal:  Acta Neuropathol       Date:  1995       Impact factor: 17.088

9.  Analysis of protein levels of 24 cytokines in scrapie agent-infected brain and glial cell cultures from mice differing in prion protein expression levels.

Authors:  Déborah Tribouillard-Tanvier; James F Striebel; Karin E Peterson; Bruce Chesebro
Journal:  J Virol       Date:  2009-08-26       Impact factor: 5.103

10.  Glimepiride reduces the expression of PrPc, prevents PrPSc formation and protects against prion mediated neurotoxicity in cell lines.

Authors:  Clive Bate; Mourad Tayebi; Luisa Diomede; Mario Salmona; Alun Williams
Journal:  PLoS One       Date:  2009-12-09       Impact factor: 3.240
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