Literature DB >> 7986021

Pneumocystis carinii is resistant to imidazole antifungal agents.

M S Bartlett1, S F Queener, M M Shaw, J D Richardson, J W Smith.   

Abstract

Because Pneumocystis carinii is closely related to fungi, drugs useful for treating mycoses have been considered for use in the treatment of P. carinii pneumonia. Six antifungal imidazole drugs were tested for their activities against P. carinii in a short-term culture screen and in animals. None of the imidazoles tested was effective in inoculated infected rats, and only miconazole showed slight effects in culture at the high concentration of 10 micrograms/ml. Analysis of cell membranes from culture-grown P. carinii showed that ergosterol, the target for this class of antifungal agents, was absent, so that the lack of effect of these agents is rational.

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Year:  1994        PMID： 7986021      PMCID： PMC284650          DOI： 10.1128/AAC.38.8.1859

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  10 in total

Review 1.  Prevention and treatment of pneumocystis pneumonia.

Authors:  H Masur
Journal:  N Engl J Med       Date:  1992-12-24       Impact factor: 91.245

2.  Mitochondrial gene sequences show fungal homology for Pneumocystis carinii.

Authors:  F J Pixley; A E Wakefield; S Banerji; J M Hopkin
Journal:  Mol Microbiol       Date:  1991-06       Impact factor: 3.501

3.  Analyses of Pneumocystis fatty acids.

Authors:  E S Kaneshiro; M T Cushion; P D Walzer; K Jayasimhulu
Journal:  J Protozool       Date:  1989 Jan-Feb

4.  Antimicrobial susceptibility of Pneumocystis carinii in culture.

Authors:  M S Bartlett; R Eichholtz; J W Smith
Journal:  Diagn Microbiol Infect Dis       Date:  1985-09       Impact factor: 2.803

5.  Pneumocystis carinii: sequence from ribosomal RNA implies a close relationship with fungi.

Authors:  S L Stringer; J R Stringer; M A Blase; P D Walzer; M T Cushion
Journal:  Exp Parasitol       Date:  1989-05       Impact factor: 2.011

6.  New rat model of Pneumocystis carinii infection.

Authors:  M S Bartlett; J A Fishman; S F Queener; M M Durkin; M A Jay; J W Smith
Journal:  J Clin Microbiol       Date:  1988-06       Impact factor: 5.948

7.  Pneumocystis carinii: improved models to study efficacy of drugs for treatment or prophylaxis of Pneumocystis pneumonia in the rat (Rattus spp.).

Authors:  M S Bartlett; J A Fishman; M M Durkin; S F Queener; J W Smith
Journal:  Exp Parasitol       Date:  1990-01       Impact factor: 2.011

8.  The beta-tubulin gene from rat and human isolates of Pneumocystis carinii.

Authors:  T D Edlind; M S Bartlett; G A Weinberg; G N Prah; J W Smith
Journal:  Mol Microbiol       Date:  1992-11       Impact factor: 3.501

9.  Pneumocystis carinii shows DNA homology with the ustomycetous red yeast fungi.

Authors:  A E Wakefield; S E Peters; S Banerji; P D Bridge; G S Hall; D L Hawksworth; L A Guiver; A G Allen; J M Hopkin
Journal:  Mol Microbiol       Date:  1992-07       Impact factor: 3.501

10.  Ribosomal RNA sequence shows Pneumocystis carinii to be a member of the fungi.

Authors:  J C Edman; J A Kovacs; H Masur; D V Santi; H J Elwood; M L Sogin
Journal:  Nature       Date:  1988-08-11       Impact factor: 49.962
  10 in total
  16 in total

Review 1.  Antifungal agents: chemotherapeutic targets and immunologic strategies.

Authors:  N H Georgopapadakou; T J Walsh
Journal:  Antimicrob Agents Chemother       Date:  1996-02       Impact factor: 5.191

Review 2.  Prevention of infection due to Pneumocystis carinii.

Authors:  J A Fishman
Journal:  Antimicrob Agents Chemother       Date:  1998-05       Impact factor: 5.191

3.  Inhibitors of delta24(25) sterol methyltransferase block sterol synthesis and cell proliferation in Pneumocystis carinii.

Authors:  J A Urbina; G Visbal; L M Contreras; G McLaughlin; R Docampo
Journal:  Antimicrob Agents Chemother       Date:  1997-07       Impact factor: 5.191

4.  Ultrastructural and biochemical alterations induced by 22,26-azasterol, a delta(24(25))-sterol methyltransferase inhibitor, on promastigote and amastigote forms of Leishmania amazonensis.

Authors:  Juliany C F Rodrigues; Márcia Attias; Carlos Rodriguez; Julio A Urbina; Wanderley de Souza
Journal:  Antimicrob Agents Chemother       Date:  2002-02       Impact factor: 5.191

5.  Development and evaluation of a molecular viability assay for Pneumocystis carinii.

Authors:  N Maher; S Vermund; M Lasbury; C Lee; M Bartlett; T R Unnasch
Journal:  J Clin Microbiol       Date:  2000-05       Impact factor: 5.948

6.  C27 to C32 sterols found in Pneumocystis, an opportunistic pathogen of immunocompromised mammals.

Authors:  E S Kaneshiro; M A Wyder
Journal:  Lipids       Date:  2000-03       Impact factor: 1.880

7.  Inhibitors of sterol biosynthesis and amphotericin B reduce the viability of pneumocystis carinii f. sp. carinii.

Authors:  E S Kaneshiro; M S Collins; M T Cushion
Journal:  Antimicrob Agents Chemother       Date:  2000-06       Impact factor: 5.191

8.  In vitro and in vivo effects of quinupristin-dalfopristin against Pneumocystis carinii.

Authors:  P D Walzer; A Ashbaugh; M Collins; M T Cushion
Journal:  Antimicrob Agents Chemother       Date:  2001-11       Impact factor: 5.191

9.  Identification of a class of sulfonamides highly active against dihydropteroate synthase form Toxoplasma gondii, Pneumocystis carinii, and Mycobacterium avium.

Authors:  L C Chio; L A Bolyard; M Nasr; S F Queener
Journal:  Antimicrob Agents Chemother       Date:  1996-03       Impact factor: 5.191

10.  Evaluation of potent inhibitors of dihydrofolate reductase in a culture model for growth of Pneumocystis carinii.

Authors:  M S Bartlett; M Shaw; P Navaran; J W Smith; S F Queener
Journal:  Antimicrob Agents Chemother       Date:  1995-11       Impact factor: 5.191
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