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Literature DB >> 7985840

Mapping and characterization of the DQ subregion of the ovine MHC.

Abstract

A map of the ovine MHC class II DQ subregion has been constructed from overlapping cosmid clones. This region consists of two loci linked on a linear tract of 130 kb DNA. Each locus consists of a DQA and a DQB gene in a tail-to-tail orientation. The genes in each locus are transcribed but only those designated DQ1 express class II molecules at the surface of mouse L cells following DNA-mediated gene transfection. The DQA1 and DQB1 genes are separated by 11 kb while the DQA2 and B2 genes are 25 kb apart. The loci are separated by 22 kb.

Entities: Gene Species

Mesh：

Substances：
DNA

Year: 1994 PMID： 7985840 DOI： 10.1111/j.1365-2052.1994.tb00200.x

Source DB: PubMed Journal: Anim Genet ISSN： 0268-9146 Impact factor: 3.169

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Cited

8 in total

1. Structural and functional diversity arising from intra- and inter-haplotype combinations of duplicated DQA and B loci within the ovine MHC.

Authors: Keith T Ballingall; Isabelle Lantier; Helen Todd; Frederic Lantier; Mara Rocchi
Journal: Immunogenetics Date: 2017-09-09 Impact factor: 2.846

8. Giant panda BAC library construction and assembly of a 650-kb contig spanning major histocompatibility complex class II region.

Authors: Chang-Jun Zeng; Hui-Juan Pan; Shao-Bin Gong; Jian-Qiu Yu; Qiu-Hong Wan; Sheng-Guo Fang
Journal: BMC Genomics Date: 2007-09-08 Impact factor: 3.969

8 in total

Mapping and characterization of the DQ subregion of the ovine MHC.

1. Structural and functional diversity arising from intra- and inter-haplotype combinations of duplicated DQA and B loci within the ovine MHC.

2. Allelic nomenclature for the duplicated MHC class II DQ genes in sheep.

3. The sheep orthologue of the HLA-DOB gene.

4. The DY sub-region of the sheep MHC contains an A/B gene pair.

5. Identification and phylogenetic analysis of 15 MHC class II DRB1 beta1 expressed alleles in a ewe-lamb flock.

6. Genomic analysis of Ovis aries (Ovar) MHC class IIa loci.

7. Characterisation of major histocompatibility complex class IIa haplotypes in an island sheep population.

8. Giant panda BAC library construction and assembly of a 650-kb contig spanning major histocompatibility complex class II region.