Literature DB >> 7985025

Requirement for intron-encoded U22 small nucleolar RNA in 18S ribosomal RNA maturation.

K T Tycowski1, M D Shu, J A Steitz.   

Abstract

The nucleoli of vertebrate cells contain a number of small RNAs that are generated by the processing of intron fragments of protein-coding gene transcripts. The host gene (UHG) for intro-encoded human U22 is unusual in that it specifies a polyadenylated but apparently noncoding RNA. Depletion of U22 from Xenopus oocytes by oligonucleotide-directed ribonuclease H targeting prevented the processing of 18S ribosomal RNA (rRNA) at both ends. The appearance of 18S rRNA was restored by injection of in vitro-synthesized U22 RNA. These results identify a cellular function for an intron-encoded small RNA.

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Year:  1994        PMID： 7985025     DOI： 10.1126/science.7985025

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  67 in total

1.  Role of the box C/D motif in localization of small nucleolar RNAs to coiled bodies and nucleoli.

Authors:  A Narayanan; W Speckmann; R Terns; M P Terns
Journal:  Mol Biol Cell       Date:  1999-07       Impact factor: 4.138

2.  snoRNA nuclear import and potential for cotranscriptional function in pre-rRNA processing.

Authors:  B A Peculis
Journal:  RNA       Date:  2001-02       Impact factor: 4.942

3.  Xenopus U3 snoRNA GAC-Box A' and Box A sequences play distinct functional roles in rRNA processing.

Authors:  A V Borovjagin; S A Gerbi
Journal:  Mol Cell Biol       Date:  2001-09       Impact factor: 4.272

4.  RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse.

Authors:  A Hüttenhofer; M Kiefmann; S Meier-Ewert; J O'Brien; H Lehrach; J P Bachellerie; J Brosius
Journal:  EMBO J       Date:  2001-06-01       Impact factor: 11.598

5.  Methods to detect antifibrillarin antibodies in patients with systemic sclerosis (SSc): a comparison.

Authors:  Josefina Huerta García; Monica Delgado Osuna; Filiberto Martinez Castrejon; Laura Guzman Enriquez; Pedro A Reyes; J Jesus Cortes Hermosillo
Journal:  J Clin Lab Anal       Date:  2004       Impact factor: 2.352

6.  Structural and sequence evolution of U17 small nucleolar RNA (snoRNA) and its phylogenetic congruence in chelonians.

Authors:  Manuela Cervelli; Marco Oliverio; Alessandro Bellini; Marco Bologna; Francesco Cecconi; Paolo Mariottini
Journal:  J Mol Evol       Date:  2003-07       Impact factor: 2.395

7.  Cbf5p, the putative pseudouridine synthase of H/ACA-type snoRNPs, can form a complex with Gar1p and Nop10p in absence of Nhp2p and box H/ACA snoRNAs.

Authors:  Anthony K Henras; Regine Capeyrou; Yves Henry; Michele Caizergues-Ferrer
Journal:  RNA       Date:  2004-09-23       Impact factor: 4.942

8.  Animal snoRNAs and scaRNAs with exceptional structures.

Authors:  Manja Marz; Andreas R Gruber; Christian Höner Zu Siederdissen; Fabian Amman; Stefan Badelt; Sebastian Bartschat; Stephan H Bernhart; Wolfgang Beyer; Stephanie Kehr; Ronny Lorenz; Andrea Tanzer; Dilmurat Yusuf; Hakim Tafer; Ivo L Hofacker; Peter F Stadler
Journal:  RNA Biol       Date:  2011-11-01       Impact factor: 4.652

9.  Conserved spacing between the box C/D and C'/D' RNPs of the archaeal box C/D sRNP complex is required for efficient 2'-O-methylation of target RNAs.

Authors:  Elizabeth Tran; Xinxin Zhang; Lela Lackey; E Stuart Maxwell
Journal:  RNA       Date:  2005-01-20       Impact factor: 4.942

10.  gar2 is a nucleolar protein from Schizosaccharomyces pombe required for 18S rRNA and 40S ribosomal subunit accumulation.

Authors:  M P Gulli; J P Girard; D Zabetakis; B Lapeyre; T Melese; M Caizergues-Ferrer
Journal:  Nucleic Acids Res       Date:  1995-06-11       Impact factor: 16.971
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