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Literature DB >> 7979967

Detection of human cytomegalovirus genome in uterus tissue.

T Furukawa¹, F Jisaki, D Sakamuro, T Takegami, T Murayama.

Abstract

To analyze persistent infection by human cytomegalovirus (HCMV) in vivo, specimens obtained from various sources and autopsied organs were examined for the presence of HCMV DNA, mRNA transcripts and antigens by polymerase chain reaction, in situ hybridization and immunostaining. The HCMV genome was detected in lung, liver, kidney, and blood vessels at an average positive rate of 15%. The highest PCR-positive rate was observed with cervical smears. Subsequent examination of uterus tissues from patients with myoma revealed HCMV transcripts and antigens in glandular epithelial cells, leukocytes, endothelial cells, and others, indicating productive HCMV infection of cervical tissue.

Entities: Disease Species

Mesh：

Substances：

Year: 1994 PMID： 7979967 DOI： 10.1007/BF01310013

Source DB: PubMed Journal: Arch Virol ISSN： 0304-8608 Impact factor: 2.574

33 in total

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4 in total

1. Human cytomegalovirus infection of placental cytotrophoblasts in vitro and in utero: implications for transmission and pathogenesis.

Authors: S Fisher; O Genbacev; E Maidji; L Pereira
Journal: J Virol Date: 2000-08 Impact factor: 5.103