Literature DB >> 7971722

Chitosan as a novel nasal delivery system for peptide drugs.

L Illum1, N F Farraj, S S Davis.   

Abstract

A nasal solution formulation of the cationic material chitosan was shown to greatly enhance the absorption of insulin across the nasal mucosa of rat and sheep. The absorption promoting effect was concentration dependent with the optimal efficacy obtained for concentrations higher than 0.2% and 0.5% in rats and sheep, respectively. The absorption promoting effect was reversible with time in a "pulse-chase" study. Histological examination of the nasal mucosa of rats exposed to a chitosan solution for 60 minutes showed little change.

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Year:  1994        PMID： 7971722     DOI： 10.1023/a:1018901302450

Source DB:  PubMed          Journal:  Pharm Res        ISSN： 0724-8741            Impact factor:   4.200


  8 in total

Review 1.  Absorption of peptides and proteins from the respiratory tract and the potential for development of locally administered vaccine.

Authors:  D T O'Hagan; L Illum
Journal:  Crit Rev Ther Drug Carrier Syst       Date:  1990       Impact factor: 4.889

2.  Effect of interpolymer complex formation on bioadhesive property and drug release phenomenon of compressed tablet consisting of chitosan and sodium hyaluronate.

Authors:  K Takayama; M Hirata; Y Machida; T Masada; T Sannan; T Nagai
Journal:  Chem Pharm Bull (Tokyo)       Date:  1990-07       Impact factor: 1.645

3.  Sustained-release and intragastric-floating granules of indomethacin using chitosan in rabbits.

Authors:  S Miyazaki; H Yamaguchi; C Yokouchi; M Takada; W M Hou
Journal:  Chem Pharm Bull (Tokyo)       Date:  1988-10       Impact factor: 1.645

4.  Directly compressed tablets containing chitin or chitosan in addition to mannitol.

Authors:  Y Sawayanagl; N Nambu; T Nagai
Journal:  Chem Pharm Bull (Tokyo)       Date:  1982-11       Impact factor: 1.645

5.  The use of chitin and chitosan as drug carriers.

Authors:  S Miyazaki; K Ishii; T Nadai
Journal:  Chem Pharm Bull (Tokyo)       Date:  1981-10       Impact factor: 1.645

6.  Use of chitosan for sustained-release preparations of water-soluble drugs.

Authors:  Y Sawayanagi; N Nambu; T Nagai
Journal:  Chem Pharm Bull (Tokyo)       Date:  1982-11       Impact factor: 1.645

Review 7.  Intranasal insulin. Clinical pharmacokinetics.

Authors:  L Illum; S S Davis
Journal:  Clin Pharmacokinet       Date:  1992-07       Impact factor: 6.447

8.  Charge selectivity of rat intestinal capillaries. Influence of polycations.

Authors:  D N Granger; P R Kvietys; M A Perry; A E Taylor
Journal:  Gastroenterology       Date:  1986-12       Impact factor: 22.682
  8 in total
  82 in total

Review 1.  Dendritic cell delivery of plasmid DNA. Applications for controlled genetic immunization.

Authors:  R J Mumper; H C Ledebur
Journal:  Mol Biotechnol       Date:  2001-09       Impact factor: 2.695

Review 2.  Absorption enhancers for nasal drug delivery.

Authors:  Stanley S Davis; Lisbeth Illum
Journal:  Clin Pharmacokinet       Date:  2003       Impact factor: 6.447

Review 3.  Engineered nanoparticulate drug delivery systems: the next frontier for oral administration?

Authors:  Roudayna Diab; Chiraz Jaafar-Maalej; Hatem Fessi; Philippe Maincent
Journal:  AAPS J       Date:  2012-07-06       Impact factor: 4.009

Review 4.  Polymeric carriers for gene delivery: chitosan and poly(amidoamine) dendrimers.

Authors:  Qingxing Xu; Chi-Hwa Wang; Daniel Wayne Pack
Journal:  Curr Pharm Des       Date:  2010-07       Impact factor: 3.116

Review 5.  Pharmacokinetic considerations of new insulin formulations and routes of administration.

Authors:  A Hoffman; E Ziv
Journal:  Clin Pharmacokinet       Date:  1997-10       Impact factor: 6.447

6.  Absorption enhancement study of astragaloside IV based on its transport mechanism in caco-2 cells.

Authors:  C R Huang; G J Wang; X L Wu; H Li; H T Xie; H Lv; J G Sun
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2006 Jan-Mar       Impact factor: 2.441

7.  The inhibitory effect of an RGD-human chitin-binding domain fusion protein on the adhesion of fibroblasts to reacetylated chitosan films.

Authors:  Vera Carvalho; Lucília Domingues; Miguel Gama
Journal:  Mol Biotechnol       Date:  2008-08-02       Impact factor: 2.695

8.  Correlation of SEC/MALLS with ultracentrifuge and viscometric data for chitosans.

Authors:  Monica Fee; Neil Errington; Kornelia Jumel; Lisbeth Illum; Alan Smith; Stephen E Harding
Journal:  Eur Biophys J       Date:  2003-06-14       Impact factor: 1.733

9.  Alginate/chitosan nanoparticles are effective for oral insulin delivery.

Authors:  B Sarmento; A Ribeiro; F Veiga; P Sampaio; R Neufeld; D Ferreira
Journal:  Pharm Res       Date:  2007-06-19       Impact factor: 4.200

10.  The biocompatible polysaccharide chitosan enhances the oral tolerance to type II collagen.

Authors:  C Porporatto; M M Canali; I D Bianco; S G Correa
Journal:  Clin Exp Immunol       Date:  2009-01       Impact factor: 4.330
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