Literature DB >> 7971164

Tetrodotoxin-blockable depolarization-activated Na+ currents in a cultured endothelial cell line derived from rat interlobar arter and human umbilical vein.

D V Gordienko1, H Tsukahara.   

Abstract

Voltage-dependent Na+ current (INa) was identified in cultured endothelial cells derived from rat interlobar artery (RIAE cells) and human umbilical vein (HUVE cells). Tetrodotoxin (TTX) reduced INa in a dose-dependent manner with the apparent dissociation constant (Kd) of 1.4 microM. Low sensitivity of INa to TTX as well as its kinetics and voltage-dependent properties indicates that voltage-gated Na channels expressed in vascular endothelial cells belong to the so-called TTX-resistant type.

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Year:  1994        PMID： 7971164     DOI： 10.1007/BF00374756

Source DB:  PubMed          Journal:  Pflugers Arch        ISSN： 0031-6768            Impact factor:   3.657


  7 in total

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  7 in total
  7 in total

Review 1.  Voltage-gated Na+ channels: multiplicity of expression, plasticity, functional implications and pathophysiological aspects.

Authors:  J K J Diss; S P Fraser; M B A Djamgoz
Journal:  Eur Biophys J       Date:  2004-02-12       Impact factor: 1.733

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3.  Selective reciprocity in antimicrobial activity versus cytotoxicity of hBD-2 and crotamine.

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5.  Angiogenic functions of voltage-gated Na+ Channels in human endothelial cells: modulation of vascular endothelial growth factor (VEGF) signaling.

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6.  Novel Pannexin-1-Coupled Signaling Cascade Involved in the Control of Endothelial Cell Function and NO-Dependent Relaxation.

Authors:  Mauricio A Lillo; Pablo S Gaete; Mariela Puebla; Pía C Burboa; Inés Poblete; Xavier F Figueroa
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7.  Nerve growth factor enhances voltage-gated Na+ channel activity and Transwell migration in Mat-LyLu rat prostate cancer cell line.

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  7 in total

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