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Literature DB >> 7969145

A novel role for DNA photolyase: binding to DNA damaged by drugs is associated with enhanced cytotoxicity in Saccharomyces cerevisiae.

Abstract

DNA photolyase binds to and repairs cyclobutane pyrimidine dimers induced by UV radiation. Here we demonstrate that in the yeast Saccharomyces cerevisiae, photolyase also binds to DNA damaged by the anticancer drugs cis-diamminedichloroplatinum (cis-DDP) and nitrogen mustard (HN2) and by the alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Surprisingly, mutations in photolyase were associated with resistance of yeast cells to cis-DDP, MNNG, 4-nitroquinoline oxide (4NQO), and HN2. Transformation of yeast photolyase mutants with the photolyase gene increased sensitivity to these agents. Thus, while the binding of photolyase to DNA damaged by UV radiation aids survival of the cell, binding to DNA damaged by other agents may interfere with cell survival, perhaps by making the lesions inaccessible to the nucleotide excision repair system.

Entities: Chemical Disease Species

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Year: 1994 PMID： 7969145 PMCID： PMC359345 DOI： 10.1128/mcb.14.12.8071-8077.1994

Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272

41 in total

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Journal: Nature Date: 1993-05-13 Impact factor: 49.962

5. Purification and characterization of a human protein that binds to damaged DNA.

Authors: B J Hwang; G Chu
Journal: Biochemistry Date: 1993-02-16 Impact factor: 3.162

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Authors: S J Brown; P J Kellett; S J Lippard
Journal: Science Date: 1993-07-30 Impact factor: 47.728

7. SSL2, a suppressor of a stem-loop mutation in the HIS4 leader encodes the yeast homolog of human ERCC-3.

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8. Lethality induced by a single site-specific double-strand break in a dispensable yeast plasmid.

Authors: C B Bennett; A L Lewis; K K Baldwin; M A Resnick
Journal: Proc Natl Acad Sci U S A Date: 1993-06-15 Impact factor: 11.205

9. Yeast RAD14 and human xeroderma pigmentosum group A DNA-repair genes encode homologous proteins.

Authors: M Bankmann; L Prakash; S Prakash
Journal: Nature Date: 1992-02-06 Impact factor: 49.962

10. Evidence for lack of DNA photoreactivating enzyme in humans.

Authors: Y F Li; S T Kim; A Sancar
Journal: Proc Natl Acad Sci U S A Date: 1993-05-15 Impact factor: 11.205

14 in total

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Authors: Nerys R Morse; Valerie Meniel; Raymond Waters
Journal: Nucleic Acids Res Date: 2002-04-15 Impact factor: 16.971

2. Interaction between UV-damaged DNA binding activity proteins and the c-Abl tyrosine kinase.

Authors: Feng Cong; Jean Tang; Byung Joon Hwang; Bao Q Vuong; Gilbert Chu; Stephen P Goff
Journal: J Biol Chem Date: 2002-07-09 Impact factor: 5.157

3. Repair of damaged DNA by Arabidopsis cell extract.

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4. Fowlpox virus encodes a novel DNA repair enzyme, CPD-photolyase, that restores infectivity of UV light-damaged virus.

Authors: V Srinivasan; W M Schnitzlein; D N Tripathy
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5. The aminoglycoside antibiotic kanamycin damages DNA bases in Escherichia coli: caffeine potentiates the DNA-damaging effects of kanamycin while suppressing cell killing by ciprofloxacin in Escherichia coli and Bacillus anthracis.

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Journal: Antimicrob Agents Chemother Date: 2012-03-05 Impact factor: 5.191

6. Synthesis and biological activity of DNA damaging agents that form decoy binding sites for the estrogen receptor.

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Journal: Proc Natl Acad Sci U S A Date: 1996-12-24 Impact factor: 11.205

Review 7. Molecular mechanisms of resistance and toxicity associated with platinating agents.

Authors: Cara A Rabik; M Eileen Dolan
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8. Rapid changes of nucleotide excision repair gene expression following UV-irradiation and cisplatin treatment of Dictyostelium discoideum.

Authors: S L Yu; S K Lee; H Alexander; S Alexander
Journal: Nucleic Acids Res Date: 1998-07-15 Impact factor: 16.971

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Authors: Chun Tsai; Vaughn Smider; Byung Joon Hwang; Gilbert Chu
Journal: Methods Mol Biol Date: 2012

Review 10. Xeroderma pigmentosum complementation group E and UV-damaged DNA-binding protein.

Authors: Jean Tang; Gilbert Chu
Journal: DNA Repair (Amst) Date: 2002-08-06