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Literature DB >> 7967490

Organization of the human genome.

Abstract

The human genome contains about 3 x 10(9) base pairs which, based on average estimates for the size of coding regions, might suggest an upper limit of about 3 million genes. Evidence from a variety of approaches indicates a much lower figure--in the range 40,000-100,000 genes. Renaturation kinetic analysis reveals the presence of many repetitive elements in the human genome. Some of these are quite simple and highly reiterated, others are more complex and exist in fewer copies. The distribution and function of some of these families and the evolution of complex genomes from simpler ones are discussed.

Entities: Species

Mesh：

Substances：
DNA

Year: 1994 PMID： 7967490 DOI： 10.1007/BF00711355

Source DB: PubMed Journal: J Inherit Metab Dis ISSN： 0141-8955 Impact factor: 4.982

19 in total

1. A second-generation linkage map of the human genome.

Authors: J Weissenbach; G Gyapay; C Dib; A Vignal; J Morissette; P Millasseau; G Vaysseix; M Lathrop
Journal: Nature Date: 1992-10-29 Impact factor: 49.962

Review 2. Telomerases.

Authors: E H Blackburn
Journal: Annu Rev Biochem Date: 1992 Impact factor: 23.643

10. An X chromosome inactivation assay based on differential methylation of a CpG island coupled to a VNTR polymorphism at the 5' end of the monoamine oxidase A gene.

Authors: R W Hendriks; Z Y Chen; H Hinds; R K Schuurman; I W Craig
Journal: Hum Mol Genet Date: 1992-06 Impact factor: 6.150

1 in total

1. Noncompetitive counteractions of DNA polymerase epsilon and ISW2/yCHRAC for epigenetic inheritance of telomere position effect in Saccharomyces cerevisiae.

Authors: Tetsushi Iida; Hiroyuki Araki
Journal: Mol Cell Biol Date: 2004-01 Impact factor: 4.272

1 in total

Organization of the human genome.

1. A second-generation linkage map of the human genome.

Review 2. Telomerases.

3. Isolation of an active human transposable element.

4. Isolation and characterization of a human variable copy number tandem repeat at Xcen-p11.22.

5. A transcribed gene in an intron of the human factor VIII gene.

6. Linkage of X-linked retinitis pigmentosa to the hypervariable DNA marker M27 beta (DXS255).

7. "Haldane's dilemma" and the rate of evolution.

8. Replication timing of genes and middle repetitive sequences.

Review 9. Highly repeated sequences in mammalian genomes.

10. An X chromosome inactivation assay based on differential methylation of a CpG island coupled to a VNTR polymorphism at the 5' end of the monoamine oxidase A gene.

1. Noncompetitive counteractions of DNA polymerase epsilon and ISW2/yCHRAC for epigenetic inheritance of telomere position effect in Saccharomyces cerevisiae.