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Literature DB >> 796415

Nomifensine in parkinsonism.

P F Teychenne, D M Park, L J Findley, F C Rose, D B Calne.

Abstract

Nomifensine, a tetrahydroisoquinolone antidepressant which facilitates dopaminergic and noradrenergic transmission, was studied in 28 Parkinsonism patients most of whom were also receiving conventional medications. Double-blind evaluations revealed a moderate therapeutic action at a mean dose level of 150 mg daily. Adverse reactions were encountered, similar to those identical by levodopa.

Entities: Chemical Disease Species

Mesh：

Substances：
Isoquinolines

Year: 1976 PMID： 796415 PMCID： PMC492568 DOI： 10.1136/jnnp.39.12.1219

Source DB: PubMed Journal: J Neurol Neurosurg Psychiatry ISSN： 0022-3050 Impact factor: 10.154

6 in total

1. Actions of dopaminergic agonists on motor function.

Authors: B Costall; R J Naylor
Journal: Adv Neurol Date: 1975

2. Effect of nomifensine on motor activity, dopamine turnover rate and cyclic 3',5;-adenosine monophosphate concentrations of rat striatum.

Authors: H J Gerhards; A Carenzi; E Costa
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1974 Impact factor: 3.000

3. Bromocriptine in Parkinsonism.

Authors: D B Calne; P F Teychenne; L E Claveria; R Eastman; J K Greenacre; A Petrie
Journal: Br Med J Date: 1974-11-23

4. Effect of nomifensine (HOE 984), a new antidepressant, on uptake of noradrenaline and serotonin and on release of noradrenaline in rat brain synaptosomes.

Authors: U Schacht; W Heptner
Journal: Biochem Pharmacol Date: 1974-12-15 Impact factor: 5.858

5. 8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline, a new antidepressant.

Authors: I Hoffmann
Journal: Arzneimittelforschung Date: 1973-01

6. Nomifensine: a potent dopaminergic agonist of antiparkinson potential.

Authors: B Costall; D M Kelly; R J Naylor
Journal: Psychopharmacologia Date: 1975

6 in total

4 in total

Nomifensine in parkinsonism.

1. Actions of dopaminergic agonists on motor function.

2. Effect of nomifensine on motor activity, dopamine turnover rate and cyclic 3',5;-adenosine monophosphate concentrations of rat striatum.

3. Bromocriptine in Parkinsonism.

4. Effect of nomifensine (HOE 984), a new antidepressant, on uptake of noradrenaline and serotonin and on release of noradrenaline in rat brain synaptosomes.

5. 8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline, a new antidepressant.

6. Nomifensine: a potent dopaminergic agonist of antiparkinson potential.

Review 1. Monoamine reuptake inhibitors in Parkinson's disease.

2. Nomifensine: effect in Parkinsonian patients not receiving levodopa.

3. Nomifensine in Parkinson's disease.

4. Nomifensine in parkinsonism.