BACKGROUND: Psoriasis vulgaris was reported to be associated with a specific alanine residue at position 73 of HLA-C alleles in Japanese patients. OBJECTIVE: Our purpose was to determine the role of HLA genes in susceptibility to psoriasis vulgaris in the Israeli Jewish population. METHODS: Twenty-eight Israeli patients were analyzed for their HLA class I and II specificities by means of serologic and molecular methods. RESULTS: All patients possessed in their HLA-C antigens an alanine residue at position 73 (p < 0.002). A significantly increased frequency of HLA-Cw6 and of Cw7 was also observed among the patients (p < 0.02). CONCLUSION: Our study clearly shows that alanine in position 73 is significantly associated with psoriasis vulgaris in Jewish patients. Cw6 and Cw7 have a unique antigen-binding pocket containing both alanine at position 73 and a negatively charged aspartic acid at position 9. These residues are most probably important in determining the conformation of the C pocket and in turn the nature of the peptide bound to it. We suggest that this combination confers the highest risk of the development of psoriasis vulgaris.
BACKGROUND:Psoriasis vulgaris was reported to be associated with a specific alanine residue at position 73 of HLA-C alleles in Japanese patients. OBJECTIVE: Our purpose was to determine the role of HLA genes in susceptibility to psoriasis vulgaris in the Israeli Jewish population. METHODS: Twenty-eight Israeli patients were analyzed for their HLA class I and II specificities by means of serologic and molecular methods. RESULTS: All patients possessed in their HLA-C antigens an alanine residue at position 73 (p < 0.002). A significantly increased frequency of HLA-Cw6 and of Cw7 was also observed among the patients (p < 0.02). CONCLUSION: Our study clearly shows that alanine in position 73 is significantly associated with psoriasis vulgaris in Jewish patients. Cw6 and Cw7 have a unique antigen-binding pocket containing both alanine at position 73 and a negatively charged aspartic acid at position 9. These residues are most probably important in determining the conformation of the C pocket and in turn the nature of the peptide bound to it. We suggest that this combination confers the highest risk of the development of psoriasis vulgaris.
Authors: R P Nair; P Stuart; T Henseler; S Jenisch; N V Chia; E Westphal; N J Schork; J Kim; H W Lim; E Christophers; J J Voorhees; J T Elder Journal: Am J Hum Genet Date: 2000-05-05 Impact factor: 11.025
Authors: G K Tay; J Hui; S Gaudieri; M Schmitt-Egenolf; O P Martinez; C Leelayuwat; J F Williamson; T H Eiermann; R L Dawkins Journal: Clin Exp Immunol Date: 2000-03 Impact factor: 4.330
Authors: Colin D Veal; Francesca Capon; Michael H Allen; Emma K Heath; Julie C Evans; Andrew Jones; Shanta Patel; David Burden; David Tillman; Jonathan N W N Barker; Richard C Trembath Journal: Am J Hum Genet Date: 2002-07-29 Impact factor: 11.025
Authors: Ivana Shawkatová; Juraj Javor; Zuzana Párnická; Peter Kozub; Mária Zilínková; Peter Frey; Stanislav Ferenčík; Milan Buc Journal: Folia Microbiol (Praha) Date: 2012-11-27 Impact factor: 2.099