Literature DB >> 7961477

Molecular cloning and characterization of the aklavinone 11-hydroxylase gene of Streptomyces peucetius subsp. caesius ATCC 27952.

Y S Hong1, C K Hwang, S K Hong, Y H Kim, J J Lee.   

Abstract

The gene encoding aklavinone 11-hydroxylase of Streptomyces peucetius subsp. caesius ATCC 27952 was cloned and sequenced. The deduced amino acid sequence of the gene contains at least two common motifs of well-conserved amino acid sequences of several flavin-type bacterial hydroxylases. The hydroxylase gene is apparently transcribed from a single transcriptional start point. The phenotype of a dnrF mutant generated by gene disruption supports the idea that the dnrF gene encodes aklavinone 11-hydroxylase.

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Year:  1994        PMID： 7961477      PMCID： PMC197087          DOI： 10.1128/jb.176.22.7096-7101.1994

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  30 in total

Review 1.  Compilation and analysis of DNA sequences associated with apparent streptomycete promoters.

Authors:  W R Strohl
Journal:  Nucleic Acids Res       Date:  1992-03-11       Impact factor: 16.971

2.  Bidirectional promoter and terminator regions bracket mmr, a resistance gene embedded in the Streptomyces coelicolor A3(2) gene cluster encoding methylenomycin production.

Authors:  R J Neal; K F Chater
Journal:  Gene       Date:  1991-04       Impact factor: 3.688

3.  An improved aminoglycoside resistance gene cassette for use in gram-negative bacteria and Streptomyces.

Authors:  F Denis; R Brzezinski
Journal:  FEMS Microbiol Lett       Date:  1991-07-01       Impact factor: 2.742

4.  Regulation of secondary metabolism in Streptomyces spp. and overproduction of daunorubicin in Streptomyces peucetius.

Authors:  K J Stutzman-Engwall; S L Otten; C R Hutchinson
Journal:  J Bacteriol       Date:  1992-01       Impact factor: 3.490

5.  The relationship between base composition and codon usage in bacterial genes and its use for the simple and reliable identification of protein-coding sequences.

Authors:  M J Bibb; P R Findlay; M W Johnson
Journal:  Gene       Date:  1984-10       Impact factor: 3.688

6.  Microbial transformation of aklanonic acid, a potential early intermediate in the biosynthesis of anthracyclines.

Authors:  C Wagner; K Eckardt; G Schumann; W Ihn; D Tresselt
Journal:  J Antibiot (Tokyo)       Date:  1984-06       Impact factor: 2.649

7.  A bacterial analog of the mdr gene of mammalian tumor cells is present in Streptomyces peucetius, the producer of daunorubicin and doxorubicin.

Authors:  P G Guilfoile; C R Hutchinson
Journal:  Proc Natl Acad Sci U S A       Date:  1991-10-01       Impact factor: 11.205

8.  Adriamycin, 14-hydroxydaunomycin, a new antitumor antibiotic from S. peucetius var. caesius.

Authors:  F Arcamone; G Cassinelli; G Fantini; A Grein; P Orezzi; C Pol; C Spalla
Journal:  Biotechnol Bioeng       Date:  1969-11       Impact factor: 4.530

9.  Expression of doxorubicin-daunorubicin resistance genes in different anthracycline-producing mutants of Streptomyces peucetius.

Authors:  A L Colombo; M M Solinas; G Perini; G Biamonti; G Zanella; M Caruso; F Torti; S Filippini; A Inventi-Solari; L Garofano
Journal:  J Bacteriol       Date:  1992-03       Impact factor: 3.490

10.  Nutrient effects on anthracycline production by Streptomyces peucetius in a defined medium.

Authors:  M L Dekleva; J A Titus; W R Strohl
Journal:  Can J Microbiol       Date:  1985-03       Impact factor: 2.419
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  4 in total

1.  Isolation and characterization of a gene from Streptomyces sp. strain C5 that confers the ability to convert daunomycin to doxorubicin on Streptomyces lividans TK24.

Authors:  M L Dickens; W R Strohl
Journal:  J Bacteriol       Date:  1996-06       Impact factor: 3.490

2.  Identification of a novel conserved sequence motif in flavoprotein hydroxylases with a putative dual function in FAD/NAD(P)H binding.

Authors:  M H Eppink; H A Schreuder; W J Van Berkel
Journal:  Protein Sci       Date:  1997-11       Impact factor: 6.725

3.  Cloning and characterization of a polyketide synthase gene from Streptomyces fradiae Tü2717, which carries the genes for biosynthesis of the angucycline antibiotic urdamycin A and a gene probably involved in its oxygenation.

Authors:  H Decker; S Haag
Journal:  J Bacteriol       Date:  1995-11       Impact factor: 3.490

4.  Expression of Streptomyces peucetius genes for doxorubicin resistance and aklavinone 11-hydroxylase in Streptomyces galilaeus ATCC 31133 and production of a hybrid aclacinomycin.

Authors:  C K Hwang; H S Kim; Y S Hong; Y H Kim; S K Hong; S J Kim; J J Lee
Journal:  Antimicrob Agents Chemother       Date:  1995-07       Impact factor: 5.191
  4 in total

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