Literature DB >> 7948833

Neuropathic pain sensations are differentially sensitive to dextrorphan.

M Tal1, G J Bennett.   

Abstract

Rats with an experimental painful peripheral neuropathy (the CCI model) display heat-hyperalgesia and mechanoallodynia. Previous work has shown that the heat-hyperalgesia is suppressed by dextrorphan (DEX) and other N-methyl-D-aspartate (NMDA) receptor antagonists. The present work shows that when tested in the same rats, a dose of DEX that is maximally effective against heat-hyperalgesia has no effect on mechano-allodynia. The results suggest that different kinds of abnormal pain sensations may be caused by different pathophysiologic mechanisms that may respond differently to drug therapy.

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Year:  1994        PMID： 7948833     DOI： 10.1097/00001756-199407000-00008

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  8 in total

Review 1.  Cellular mechanisms of neuropathic pain, morphine tolerance, and their interactions.

Authors:  D J Mayer; J Mao; J Holt; D D Price
Journal:  Proc Natl Acad Sci U S A       Date:  1999-07-06       Impact factor: 11.205

Review 2.  Glutamate receptors and nociception: implications for the drug treatment of pain.

Authors:  M E Fundytus
Journal:  CNS Drugs       Date:  2001-01       Impact factor: 5.749

3.  Neuropathic insult increases the responsiveness to acetic acid in mice.

Authors:  Cenk O Gurdap; Patrick S Markwalter; Bradley Neddenriep; Deniz Bagdas; M Imad Damaj
Journal:  Behav Pharmacol       Date:  2019-09       Impact factor: 2.293

4.  Long-term changes in behavior and regional cerebral blood flow associated with painful peripheral mononeuropathy in the rat.

Authors:  Pamela E Paulson; Kenneth L Casey; Thomas J Morrow
Journal:  Pain       Date:  2002-01       Impact factor: 6.961

5.  TREK-1, a K+ channel involved in polymodal pain perception.

Authors:  Abdelkrim Alloui; Katharina Zimmermann; Julien Mamet; Fabrice Duprat; Jacques Noël; Jean Chemin; Nicolas Guy; Nicolas Blondeau; Nicolas Voilley; Catherine Rubat-Coudert; Marc Borsotto; Georges Romey; Catherine Heurteaux; Peter Reeh; Alain Eschalier; Michel Lazdunski
Journal:  EMBO J       Date:  2006-05-04       Impact factor: 11.598

6.  After-effects of consecutive sessions of transcranial direct current stimulation (tDCS) in a rat model of chronic inflammation.

Authors:  Gabriela Laste; Wolnei Caumo; Lauren Naomi Spezia Adachi; Joanna Ripoll Rozisky; Isabel Cristina de Macedo; Paulo Ricardo Marques Filho; Wania Aparecida Partata; Felipe Fregni; Iraci L S Torres
Journal:  Exp Brain Res       Date:  2012-07-03       Impact factor: 1.972

Review 7.  Central sensitization: a generator of pain hypersensitivity by central neural plasticity.

Authors:  Alban Latremoliere; Clifford J Woolf
Journal:  J Pain       Date:  2009-09       Impact factor: 5.820

8.  Manganese Oxide Nanozymes Ameliorate Mechanical Allodynia in a Rat Model of Partial Sciatic Nerve-Transection Induced Neuropathic Pain.

Authors:  Yaswanth Kuthati; Prabhakar Busa; Venkata Naga Goutham Davuluri; Chih Shung Wong
Journal:  Int J Nanomedicine       Date:  2019-12-27
  8 in total

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