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Literature DB >> 7947096

Loss of heterozygosity on chromosome 22 in ovarian carcinoma is distal to and is not accompanied by mutations in NF2 at 22q12.

P Englefield¹, W D Foulkes, I G Campbell.

Abstract

Frequent loss of heterozygosity (LOH) has been reported on 22q in ovarian carcinoma, implying the presence of a tumour-suppressor gene. The neurofibromatosis type 2 gene (NF2) at 22q12 is a plausible candidate. Analysis of 9 of the 17 exons of NF2 by single-strand conformational polymorphism (SSCP) in 67 ovarian carcinomas did not detect any somatic mutations, suggesting that NF2 is not involved in the pathogenesis of ovarian carcinoma. LOH data support this conclusion and that the putative tumour-suppressor gene lies distal to NF2, beyond D22S283.

Entities: Disease Gene

Mesh：

Year: 1994 PMID： 7947096 PMCID： PMC2033554 DOI： 10.1038/bjc.1994.418

Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640

31 in total

1. A second-generation linkage map of the human genome.

Authors: J Weissenbach; G Gyapay; C Dib; A Vignal; J Morissette; P Millasseau; G Vaysseix; M Lathrop
Journal: Nature Date: 1992-10-29 Impact factor: 49.962

2. Loss of constitutional heterozygosity in colon carcinoma from patients with familial polyposis coli.

Authors: M Okamoto; M Sasaki; K Sugio; C Sato; T Iwama; T Ikeuchi; A Tonomura; T Sasazuki; M Miyaki
Journal: Nature Date: 1988-01-21 Impact factor: 49.962

3. Somatic mutations in the neurofibromatosis 1 gene in human tumors.

Authors: Y Li; G Bollag; R Clark; J Stevens; L Conroy; D Fults; K Ward; E Friedman; W Samowitz; M Robertson
Journal: Cell Date: 1992-04-17 Impact factor: 41.582

4. Loss of heterozygosity in familial breast carcinomas.

Authors: A Lindblom; L Skoog; S Rotstein; B Werelius; C Larsson; M Nordenskjöld
Journal: Cancer Res Date: 1993-09-15 Impact factor: 12.701

5. Allelotype of human ovarian cancer.

Authors: T Sato; H Saito; R Morita; S Koi; J H Lee; Y Nakamura
Journal: Cancer Res Date: 1991-10-01 Impact factor: 12.701

6. A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor.

Authors: J A Trofatter; M M MacCollin; J L Rutter; J R Murrell; M P Duyao; D M Parry; R Eldridge; N Kley; A G Menon; K Pulaski
Journal: Cell Date: 1993-03-12 Impact factor: 41.582

7. Heterogeneity for allelic loss in human breast cancer.

Authors: L C Chen; W Kurisu; B M Ljung; E S Goldman; D Moore; H S Smith
Journal: J Natl Cancer Inst Date: 1992-04-01 Impact factor: 13.506

8. Allelotype of breast cancer: cumulative allele losses promote tumor progression in primary breast cancer.

Authors: T Sato; A Tanigami; K Yamakawa; F Akiyama; F Kasumi; G Sakamoto; Y Nakamura
Journal: Cancer Res Date: 1990-11-15 Impact factor: 12.701

9. Frequent loss of heterozygosity on chromosome 6 in human ovarian carcinoma.

Authors: W D Foulkes; J Ragoussis; G W Stamp; G J Allan; J Trowsdale
Journal: Br J Cancer Date: 1993-03 Impact factor: 7.640

10. Loss of heterozygosity and amplification on chromosome 11q in human ovarian cancer.

Authors: W D Foulkes; I G Campbell; G W Stamp; J Trowsdale
Journal: Br J Cancer Date: 1993-02 Impact factor: 7.640

6 in total

1. Detailed deletion mapping of loss of heterozygosity on 22q13 in sporadic colorectal cancer.

Authors: Hai-Tao Zheng; Zhi-Hai Peng; Chong-Zhi Zhou; Da-Peng Li; Zhao-Wen Wang; Guo-Qiang Qiu; Lin He
Journal: World J Gastroenterol Date: 2005-03-21 Impact factor: 5.742

2. Amplification of D22S283 as a favorable prognostic indicator in liver fluke related cholangiocarcinoma.

Authors: Jongkonnee Thanasai; Temduang Limpaiboon; Patcharee Jearanaikoon; Vajarabhongsa Bhudhisawasdi; Narong Khuntikeo; Banchob Sripa; Masanao Miwa
Journal: World J Gastroenterol Date: 2006-07-21 Impact factor: 5.742

3. High frequency of inactivating mutations in the neurofibromatosis type 2 gene (NF2) in primary malignant mesotheliomas.

Authors: A B Bianchi; S I Mitsunaga; J Q Cheng; W M Klein; S C Jhanwar; B Seizinger; N Kley; A J Klein-Szanto; J R Testa
Journal: Proc Natl Acad Sci U S A Date: 1995-11-21 Impact factor: 11.205