Literature DB >> 7947043

Acute leucoencephalopathy during cyclosporin A therapy in a patient with nephrotic syndrome.

C Shimizu1, S Kimura, Y Yoshida, A Nezu, K Saitoh, H Osaka, Y Aihara, Y Nagasaka.   

Abstract

A 13-year-old girl with nephrotic syndrome (NS) developed acute leucoencephalopathy during combination therapy with cyclosporin A (CyA) and prednisolone (PSL). The patient had a generalized motor seizure followed by coma at 19 days after CyA administration. Magnetic resonance scanning performed on the 1st hospital day revealed white matter lesions in the subcortices of the parietal and occipital lobes, brain stem and cerebellum. These lesions had completely resolved on the 10th hospital day. This episode might be caused by CyA because the clinical course and laboratory data revealed neither inflammation nor other causative factors. To our knowledge, this is the first report of acute leucoencephalopathy during combination therapy with CyA and PSL in a patient with NS.

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Year:  1994        PMID： 7947043     DOI： 10.1007/bf00856540

Source DB:  PubMed          Journal:  Pediatr Nephrol        ISSN： 0931-041X            Impact factor:   3.714


  12 in total

1.  Cyclosporin leukoencephalopathy induced by intravenous lipid solution.

Authors:  N De Klippel; J Sennesael; J Lamote; G Ebinger; J de Keyser
Journal:  Lancet       Date:  1992-05-02       Impact factor: 79.321

2.  Remission of idiopathic nephrotic syndrome after treatment with cyclosporin A.

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Journal:  Br Med J (Clin Res Ed)       Date:  1986-03-22

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Authors:  M H Deierhoi; M Kalayoglu; H W Sollinger; F O Belzer
Journal:  Transplant Proc       Date:  1988-02       Impact factor: 1.066

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Authors:  J H Berden; A J Hoitsma; J L Merx; A Keyser
Journal:  Lancet       Date:  1985-01-26       Impact factor: 79.321

5.  Cyclosporin neurotoxicity in cardiac transplant recipients.

Authors:  R J Lane; S W Roche; A A Leung; A Greco; L S Lange
Journal:  J Neurol Neurosurg Psychiatry       Date:  1988-11       Impact factor: 10.154

6.  Severe neurologic toxicity induced by cyclosporine A in three renal transplant patients.

Authors:  B F Palmer; R D Toto
Journal:  Am J Kidney Dis       Date:  1991-07       Impact factor: 8.860

7.  Central nervous system toxicity after liver transplantation. The role of cyclosporine and cholesterol.

Authors:  P C de Groen; A J Aksamit; J Rakela; G S Forbes; R A Krom
Journal:  N Engl J Med       Date:  1987-10-01       Impact factor: 91.245

Review 8.  Neurologic complications of immunosuppressive agents.

Authors:  R W Walker; J A Brochstein
Journal:  Neurol Clin       Date:  1988-05       Impact factor: 3.806

9.  Cerebral blindness and encephalopathy with cyclosporin A toxicity.

Authors:  A M Rubin; H Kang
Journal:  Neurology       Date:  1987-06       Impact factor: 9.910

10.  Cyclosporin A inhibits acute serum sickness nephritis in rabbits.

Authors:  G H Neild; K Ivory; M Hiramatsu; D G Williams
Journal:  Clin Exp Immunol       Date:  1983-06       Impact factor: 4.330
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  3 in total

1.  Deoxyspergualin, an immunosuppressant, in patients suffering from nephropathies with crescent formation: an open-label trial to evaluate safety and efficacy.

Authors:  Hirokazu Imai; Osamu Hotta; Mitsuhiro Yoshimura; Tsuneo Konta; Yoshiharu Tsubakihara; Masanobu Miyazaki; Chie Tomida; Masaki Kobayashi; Satoshi Suzuki; Hideo Shiiki; Atsushi Yamauchi; Hitoshi Yokoyama; Masato Nose
Journal:  Clin Exp Nephrol       Date:  2006-03       Impact factor: 2.801

2.  Central neurotoxicity of cyclosporine in two children with nephrotic syndrome.

Authors:  Sophie Taque; Sylviane Peudenier; Sophie Gie; Marc Rambeau; Virginie Gandemer; Laure Bridoux; Pierre Bétrémieux; Loic De Parscau; Edouard Le Gall
Journal:  Pediatr Nephrol       Date:  2004-02-03       Impact factor: 3.714

3.  Rituximab is a safe and effective long-term treatment for children with steroid and calcineurin inhibitor-dependent idiopathic nephrotic syndrome.

Authors:  Pietro Ravani; Alessandro Ponticelli; Chiara Siciliano; Alessia Fornoni; Alberto Magnasco; Felice Sica; Monica Bodria; Gianluca Caridi; Changli Wei; Mirco Belingheri; Luciana Ghio; Sandra Merscher-Gomez; Alberto Edefonti; Andrea Pasini; Giovanni Montini; Corrado Murtas; Xiangyu Wang; Daniel Muruve; Augusto Vaglio; Davide Martorana; Antonello Pani; Francesco Scolari; Jochen Reiser; Gian M Ghiggeri
Journal:  Kidney Int       Date:  2013-06-05       Impact factor: 10.612
  3 in total

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