Literature DB >> 3069960

Cyclosporin neurotoxicity in cardiac transplant recipients.

R J Lane1, S W Roche, A A Leung, A Greco, L S Lange.   

Abstract

Cyclosporin toxicity may produce a wide range of neurological disorders. We report three patients whose neurological problems developed while taking cyclosporin following cardiac transplantation, but resolved rapidly when the drug was discontinued. In two cases, MRI revealed abnormalities which disappeared with clinical recovery. Blood cyclosporin concentrations were not markedly increased, and it is possible that the neurotoxic effects of cyclosporin are mediated by metabolites, through an effect on the blood-brain barrier.

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Year:  1988        PMID： 3069960      PMCID： PMC1032815          DOI： 10.1136/jnnp.51.11.1434

Source DB:  PubMed          Journal:  J Neurol Neurosurg Psychiatry        ISSN： 0022-3050            Impact factor:   10.154


  10 in total

1.  Cyclosporin metabolites and central-nervous-system toxicity.

Authors:  U Kunzendorf; J Brockmöller; F Jochimsen; F Keller; G Walz; G Offermann
Journal:  Lancet       Date:  1988-05-28       Impact factor: 79.321

2.  Severe central-nervous-system toxicity associated with cyclosporin.

Authors:  J H Berden; A J Hoitsma; J L Merx; A Keyser
Journal:  Lancet       Date:  1985-01-26       Impact factor: 79.321

3.  Cyclosporin-associated fatal convulsions.

Authors:  T Velu; L Debusscher; P A Stryckmans
Journal:  Lancet       Date:  1985-01-26       Impact factor: 79.321

4.  Disturbance of blood-brain barrier after bone-marrow transplantation.

Authors:  J P Sloane; K Y Lwin; M E Gore; R L Powles; J F Smith
Journal:  Lancet       Date:  1985-08-03       Impact factor: 79.321

5.  Cyclosporine-associated central-nervous-system toxicity after allogeneic bone-marrow transplantation.

Authors:  K Atkinson; J Biggs; P Darveniza; J Boland; A Concannon; A Dodds
Journal:  N Engl J Med       Date:  1984-02-23       Impact factor: 91.245

6.  Generalised epileptic fits in renal transplant recipients given cyclosporin A.

Authors:  D Shah; P B Rylance; M E Rogerson; M Bewick; V Parsons
Journal:  Br Med J (Clin Res Ed)       Date:  1984-11-17

7.  Convulsions associated with cyclosporin A in renal transplant recipients.

Authors:  M L Gross; R M Pearson; P Sweny; J F Moorhead
Journal:  Br Med J (Clin Res Ed)       Date:  1985-02-16

8.  Targeted blood levels of cyclosporin for cardiac transplantation.

Authors:  B P Griffith; R L Hardesty; A Trento; A Lee; H T Bahnson
Journal:  J Thorac Cardiovasc Surg       Date:  1984-12       Impact factor: 5.209

9.  Cerebral blindness and encephalopathy with cyclosporin A toxicity.

Authors:  A M Rubin; H Kang
Journal:  Neurology       Date:  1987-06       Impact factor: 9.910

10.  Association between cyclosporin neurotoxicity and hypomagnesaemia.

Authors:  C B Thompson; C H June; K M Sullivan; E D Thomas
Journal:  Lancet       Date:  1984-11-17       Impact factor: 79.321
  10 in total
  12 in total

1.  Variable incidence of cyclosporine and FK-506 neurotoxicity in hematopoeitic malignancies and marrow conditions after allogeneic bone marrow transplantation.

Authors:  Walter S Bartynski; Zella R Zeigler; Richard K Shadduck; John Lister
Journal:  Neurocrit Care       Date:  2005       Impact factor: 3.210

2.  Current status of psychological research in organ transplantation.

Authors:  J R Rodrigue; A F Greene; S R Boggs
Journal:  J Clin Psychol Med Settings       Date:  1994-03

3.  Etiology of cortical and white matter lesions in cyclosporin-A and FK-506 neurotoxicity.

Authors:  W S Bartynski; Z Zeigler; M P Spearman; L Lin; R K Shadduck; J Lister
Journal:  AJNR Am J Neuroradiol       Date:  2001 Nov-Dec       Impact factor: 3.825

Review 4.  The pathophysiology of Sandimmune (cyclosporine) in man and animals.

Authors:  J Mason
Journal:  Pediatr Nephrol       Date:  1990-11       Impact factor: 3.714

Review 5.  Neurologic Complications of Transplantation.

Authors:  Rajat Dhar
Journal:  Neurocrit Care       Date:  2018-02       Impact factor: 3.210

6.  Progressive visual deterioration leading to blindness after pediatric heart transplantation.

Authors:  K O Schowengerdt; R J Gajarski; S Denfield
Journal:  Tex Heart Inst J       Date:  1993

7.  Cyclosporin A toxicity: MRI appearance of the brain.

Authors:  M T Pace; T L Slovis; J K Kelly; S D Abella
Journal:  Pediatr Radiol       Date:  1995

8.  Pretransplantation conditioning influence on the occurrence of cyclosporine or FK-506 neurotoxicity in allogeneic bone marrow transplantation.

Authors:  Walter S Bartynski; Zella R Zeigler; Richard K Shadduck; John Lister
Journal:  AJNR Am J Neuroradiol       Date:  2004-02       Impact factor: 3.825

9.  CNS aspergillosis in organ transplantation: a clinicopathological study.

Authors:  J Torre-Cisneros; O L Lopez; S Kusne; A J Martinez; T E Starzl; R L Simmons; M Martin
Journal:  J Neurol Neurosurg Psychiatry       Date:  1993-02       Impact factor: 10.154

Review 10.  Acute leucoencephalopathy during cyclosporin A therapy in a patient with nephrotic syndrome.

Authors:  C Shimizu; S Kimura; Y Yoshida; A Nezu; K Saitoh; H Osaka; Y Aihara; Y Nagasaka
Journal:  Pediatr Nephrol       Date:  1994-08       Impact factor: 3.714
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