Literature DB >> 7946923

Vanadium compounds. Their action on alkaline phosphatase activity.

A M Cortizo1, V C Salice, S B Etcheverry.   

Abstract

The direct effect of different vanadium compounds upon alkaline phosphatase (ALP) activity was investigated. Vanadate and vanadyl inhibited both the soluble and particulate ALP activity from UMR.106 cells and from bovine intestinal ALP. We have also shown the inhibition of ALP activity in the soluble fraction of osteoblasts by peroxo and hydroperoxo vanadium compounds. ALP activity in the particulate fraction was not inhibited by these species; nor was the bovine intestinal ALP. Using inhibitors of Tyr-phosphatase (PTPases), the soluble ALP was partially characterized as a PTPase. The major activity in the particulate fraction represents the bone-specific ALP-activity. This study demonstrates that different forms of vanadium are direct inhibitors of ALP activity. This effect is dependent on the enzymatic activity investigated and on the origin of the ALP.

Entities:  

Mesh：

Substances：

Year:  1994        PMID： 7946923     DOI： 10.1007/bf02917433

Source DB:  PubMed          Journal:  Biol Trace Elem Res        ISSN： 0163-4984            Impact factor:   3.738


  13 in total

1.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

Authors:  M M Bradford
Journal:  Anal Biochem       Date:  1976-05-07       Impact factor: 3.365

Review 2.  Phosphotyrosyl protein phosphatases.

Authors:  K H Lau; J R Farley; D J Baylink
Journal:  Biochem J       Date:  1989-01-01       Impact factor: 3.857

Review 3.  Growth factor receptor tyrosine kinases.

Authors:  Y Yarden; A Ullrich
Journal:  Annu Rev Biochem       Date:  1988       Impact factor: 23.643

4.  Mechanism of porphobilinogen synthase. Requirement of Zn2+ for enzyme activity.

Authors:  D R Bevan; P Bodlaender; D Shemin
Journal:  J Biol Chem       Date:  1980-03-10       Impact factor: 5.157

5.  Mechanism of vanadate-induced activation of tyrosine phosphorylation and of the respiratory burst in HL60 cells. Role of reduced oxygen metabolites.

Authors:  S Trudel; M R Pâquet; S Grinstein
Journal:  Biochem J       Date:  1991-06-15       Impact factor: 3.857

6.  Evidence for protein-tyrosine-phosphatase catalysis proceeding via a cysteine-phosphate intermediate.

Authors:  K L Guan; J E Dixon
Journal:  J Biol Chem       Date:  1991-09-15       Impact factor: 5.157

Review 7.  Growth hormone and bone.

Authors:  R Bouillon
Journal:  Horm Res       Date:  1991

8.  Glutathione reduces cytoplasmic vanadate. Mechanism and physiological implications.

Authors:  I G Macara; K Kustin; L C Cantley
Journal:  Biochim Biophys Acta       Date:  1980-04-17

9.  Pervanadate [peroxide(s) of vanadate] mimics insulin action in rat adipocytes via activation of the insulin receptor tyrosine kinase.

Authors:  I G Fantus; S Kadota; G Deragon; B Foster; B I Posner
Journal:  Biochemistry       Date:  1989-10-31       Impact factor: 3.162

10.  Characterization of the major protein-tyrosine-phosphatases of human placenta.

Authors:  N K Tonks; C D Diltz; E H Fischer
Journal:  J Biol Chem       Date:  1988-05-15       Impact factor: 5.157
View more
  6 in total

1.  Synthesis, characterization, antitumoral and osteogenic activities of quercetin vanadyl(IV) complexes.

Authors:  Evelina G Ferrer; María V Salinas; María J Correa; Luciana Naso; Daniel A Barrio; Susana B Etcheverry; Luis Lezama; Teófilo Rojo; Patricia A M Williams
Journal:  J Biol Inorg Chem       Date:  2006-07-05       Impact factor: 3.358

Review 2.  New insights into mineralogenic effects of vanadate.

Authors:  Vincent Laizé; Daniel M Tiago; Manuel Aureliano; M Leonor Cancela
Journal:  Cell Mol Life Sci       Date:  2009-09-04       Impact factor: 9.261

3.  Effect of vanadium compounds on acid phosphatase activity.

Authors:  C M Vescina; V C Sálice; A M Cortizo; S B Etcheverry
Journal:  Biol Trace Elem Res       Date:  1996       Impact factor: 3.738

4.  Effects on the bones of vanadyl acetylacetonate by oral administration: a comparison study in diabetic rats.

Authors:  Shuang-Qing Zhang; Guo-Hua Chen; Wan-Liang Lu; Qiang Zhang
Journal:  J Bone Miner Metab       Date:  2007-08-25       Impact factor: 2.626

5.  Vanadium derivatives act as growth factor--mimetic compounds upon differentiation and proliferation of osteoblast-like UMR106 cells.

Authors:  A M Cortizo; S B Etcheverry
Journal:  Mol Cell Biochem       Date:  1995-04-26       Impact factor: 3.396

6.  The renal effects of vanadate exposure: potential biomarkers and oxidative stress as a mechanism of functional renal disorders--preliminary studies.

Authors:  Agnieszka Ucibior; Dorota Gołębiowska; Agnieszka Adamczyk; Irmina Niedźwiecka; Emilia Fornal
Journal:  Biomed Res Int       Date:  2014-01-28       Impact factor: 3.411
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.