Literature DB >> 7944539

Bone marrow suppression induced by high dose valproic acid.

T Kishi1, N Fujita, H Kawaguchi, M Ishimae, K Watanabe, T Tanaka.   

Abstract

A girl with intractable epilepsy who received high dose valproic acid showed bone marrow suppression, which improved after the end of valproic acid treatment and the administration of supportive treatments. Valproic acid markedly suppressed the in vitro colony growth in this patient. It is believed that high dose valproic acid treatment directly suppressed the growth of haematopoietic progenitors, resulting in bone marrow failure.

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Year:  1994        PMID： 7944539      PMCID： PMC1029950          DOI： 10.1136/adc.71.2.153

Source DB:  PubMed          Journal:  Arch Dis Child        ISSN： 0003-9888            Impact factor:   3.791


  6 in total

1.  Valproic acid-induced cytopenias: evidence for a dose-related suppression of hematopoiesis.

Authors:  R G Watts; P D Emanuel; K S Zuckerman; T H Howard
Journal:  J Pediatr       Date:  1990-09       Impact factor: 4.406

2.  Severe hematologic toxicity of valproic acid. A report of four patients.

Authors:  D J Ganick; T Sunder; J L Finley
Journal:  Am J Pediatr Hematol Oncol       Date:  1990

3.  Human bone marrow colony growth in agar-gel.

Authors:  B L Pike; W A Robinson
Journal:  J Cell Physiol       Date:  1970-08       Impact factor: 6.384

4.  Hemopoietic colony-forming cells in umbilical cord blood with extensive capability to generate mono- and multipotential hemopoietic progenitors.

Authors:  T Nakahata; M Ogawa
Journal:  J Clin Invest       Date:  1982-12       Impact factor: 14.808

5.  Treatment of intractable childhood epilepsy with high-dose valproate.

Authors:  Y Ohtsuka; R Amano; M Mizukawa; E Oka; S Ohtahara
Journal:  Epilepsia       Date:  1992 Jan-Feb       Impact factor: 5.864

6.  Sodium valproate and bone marrow suppression.

Authors:  F R Smith; M Boots
Journal:  Ann Neurol       Date:  1980-08       Impact factor: 10.422
  6 in total
  4 in total

1.  Sodium valproate facilitates the propagation of granulocytic ehrlichiae (Anaplasma phagocytophilum) in HL-60 cells.

Authors:  Petir Zeman; Jaroslav Cinatl; Hana Kabickova
Journal:  Exp Appl Acarol       Date:  2002       Impact factor: 2.132

2.  Targeting Bone Marrow to Potentiate the Anti-Tumor Effect of Tyrosine Kinase Inhibitor in Preclinical Rat Model of Human Glioblastoma.

Authors:  S Shaaban; M Alsulami; S A Arbab; R Ara; A Shankar; A Iskander; K Angara; M Jain; H Bagher-Ebadian; B R Achyut; A S Arbab
Journal:  Int J Cancer Res       Date:  2016-03-15

3.  Severe Pancytopenia Induced by Valproic Acid.

Authors:  Andrew Wahba; Emmalee Bergez
Journal:  Cureus       Date:  2020-10-30

Review 4.  Valproic acid and fatalities in children: a review of individual case safety reports in VigiBase.

Authors:  Kristina Star; I Ralph Edwards; Imti Choonara
Journal:  PLoS One       Date:  2014-10-10       Impact factor: 3.240
  4 in total

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