Literature DB >> 7944301

Autoantibodies to glutamic acid decarboxylase in palatal myoclonus and epilepsy.

R Nemni1, S Braghi, M G Natali-Sora, V Lampasona, E Bonifacio, G Comi, N Canal.   

Abstract

We report the presence of serum autoantibodies directed against glutamic acid decarboxylase in a patient with epilepsy and palatal myoclonus not associated with brain lesions. Glutamic acid decarboxylase antibody reactivity was dependent on the presence of carboxy-terminal amino acids, similar to that reported in patients with stiff-man syndrome. Marked reduction in the frequency of epileptic attacks and improvement in palatal myoclonus occurred when benzodiazepine was administered and phenytoin was gradually tapered. Testing for anti-glutamic acid decarboxylase antibodies may be indicated in patients with palatal myoclonus and with convulsive disorders refractory to therapy.

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Year:  1994        PMID： 7944301     DOI： 10.1002/ana.410360419

Source DB:  PubMed          Journal:  Ann Neurol        ISSN： 0364-5134            Impact factor:   10.422


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