Literature DB >> 12882238

Cerebellar ataxia associated with anti-glutamic acid decarboxylase autoantibodies.

M Vianello1, B Tavolato, M Armani, B Giometto.   

Abstract

Recent reports describe the detection of high titres of antibodies to glutamic acid decarboxylase (GAD-Ab) in the serum and cerebrospinal fluid (CSF) of patients with cerebellar ataxia. Most of these cases are females with Polyglandular Autoimmune Disorder who develop a chronic cerebellar syndrome. The CSF profile is in keeping with an autoimmune disorder and intrathecal GAD-Ab synthesis has been demonstrated. The ataxia could reverse after immunomodulatory treatments suggesting a possible pathogenetic role for GAD-Ab.

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Year:  2003        PMID： 12882238     DOI： 10.1080/14734220309432

Source DB:  PubMed          Journal:  Cerebellum        ISSN： 1473-4222            Impact factor:   3.847


  20 in total

1.  Temporal-lobe epilepsy associated with glutamic-acid-decarboxylase autoantibodies.

Authors:  B Giometto; P Nicolao; M Macucci; B Tavolato; R Foxon; G F Bottazzo
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2.  Detection of paraneoplastic anti-neuronal autoantibodies on paraffin-embedded tissues.

Authors:  B Giometto; T Scaravilli; P Nicolao; S F An; M Groves; B Tavolato; A A Beckett; F Scaravilli
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3.  Autoantibodies to glutamic acid decarboxylase in patients with therapy-resistant epilepsy.

Authors:  J Peltola; P Kulmala; J Isojärvi; A Saiz; K Latvala; J Palmio; K Savola; M Knip; T Keränen; F Graus
Journal:  Neurology       Date:  2000-07-12       Impact factor: 9.910

4.  Anti-gabaergic neuron autoantibodies in a patient with stiff-man syndrome and ataxia.

Authors:  B Giometto; D Miotto; F Faresin; V Argentiero; T Scaravilli; B Tavolato
Journal:  J Neurol Sci       Date:  1996-11       Impact factor: 3.181

5.  The aetiology of sporadic adult-onset ataxia.

Authors:  M Abele; K Bürk; L Schöls; S Schwartz; I Besenthal; J Dichgans; C Zühlke; O Riess; T Klockgether
Journal:  Brain       Date:  2002-05       Impact factor: 13.501

6.  Cerebellar ataxia with anti-glutamic acid decarboxylase antibodies: study of 14 patients.

Authors:  J Honnorat; A Saiz; B Giometto; A Vincent; L Brieva; C de Andres; J Maestre; N Fabien; A Vighetto; R Casamitjana; C Thivolet; B Tavolato; J Antoine; P Trouillas; F Graus
Journal:  Arch Neurol       Date:  2001-02

7.  Autoantibodies to glutamic acid decarboxylase in three patients with cerebellar ataxia, late-onset insulin-dependent diabetes mellitus, and polyendocrine autoimmunity.

Authors:  A Saiz; J Arpa; A Sagasta; R Casamitjana; J J Zarranz; E Tolosa; F Graus
Journal:  Neurology       Date:  1997-10       Impact factor: 9.910

Review 8.  Glutamic acid decarboxylase--gene to antigen to disease.

Authors:  A Lernmark
Journal:  J Intern Med       Date:  1996-11       Impact factor: 8.989

9.  Glutamic acid decarboxylase autoantibodies in stiff-man syndrome and insulin-dependent diabetes mellitus exhibit similarities and differences in epitope recognition.

Authors:  K Daw; N Ujihara; M Atkinson; A C Powers
Journal:  J Immunol       Date:  1996-01-15       Impact factor: 5.422

10.  Autoantibodies to glutamic acid decarboxylase in a patient with stiff-man syndrome, epilepsy, and type I diabetes mellitus.

Authors:  M Solimena; F Folli; S Denis-Donini; G C Comi; G Pozza; P De Camilli; A M Vicari
Journal:  N Engl J Med       Date:  1988-04-21       Impact factor: 91.245
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  11 in total

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Authors:  Esther Ganelin-Cohen; Dalit Modan-Moses; Rina Hemi; Hannah Kanety; Bruria Ben-Zeev; Christiane S Hampe
Journal:  Pediatr Diabetes       Date:  2015-12-29       Impact factor: 4.866

2.  Stiff person-syndrome IgG affects presynaptic GABAergic release mechanisms.

Authors:  Christian Werner; Holger Haselmann; Andreas Weishaupt; Klaus V Toyka; Claudia Sommer; Christian Geis
Journal:  J Neural Transm (Vienna)       Date:  2014-07-03       Impact factor: 3.575

3.  Low-titer anti-GAD-antibody-positive cerebellar ataxia.

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Journal:  Cerebellum       Date:  2013-04       Impact factor: 3.847

4.  High titers of autoantibodies to glutamate decarboxylase in type 1 diabetes patients: epitope analysis and inhibition of enzyme activity.

Authors:  Christiane S Hampe; Murray E Maitland; Lisa K Gilliam; Thanh-H Thi Phan; Ian R Sweet; Jared R Radtke; Vasile Bota; Bruce R Ransom; Irl B Hirsch
Journal:  Endocr Pract       Date:  2013 Jul-Aug       Impact factor: 3.443

5.  Respective implications of glutamate decarboxylase antibodies in stiff person syndrome and cerebellar ataxia.

Authors:  Mario U Manto; Christiane S Hampe; Véronique Rogemond; Jérome Honnorat
Journal:  Orphanet J Rare Dis       Date:  2011-02-04       Impact factor: 4.123

Review 6.  Recent Advances and Review on Treatment of Stiff Person Syndrome in Adults and Pediatric Patients.

Authors:  Adnan Bashir Bhatti; Zarine Anwar Gazali
Journal:  Cureus       Date:  2015-12-22

7.  Anti-glutamate Dehydrogenase Antibody Positive Cerebellar Ataxia and Stiff Person Syndrome Responding to Dual Treatment with Steroids and Intravenous Immunoglobulin: A Case Presentation and Literature Review.

Authors:  Furkan M Yilmaz; Dena Little; Micheal Gallagher; Amy Colcher
Journal:  Cureus       Date:  2019-06-06

8.  A Case of Anti-glutamic Acid Decarboxylase-65 Antibody Positive Stiff Person Syndrome Presenting Initially as Acute Peripheral Vestibulopathy, Leading to Delayed Diagnosis After Multiple Hospitalizations.

Authors:  Yash Nene; Tejas Mehta; Sanjay Pawar; Gajanan Patil; Nasli R Ichaporia
Journal:  Cureus       Date:  2019-11-06

9.  Monoclonal antibodies to 65kDa glutamate decarboxylase induce epitope specific effects on motor and cognitive functions in rats.

Authors:  Christiane S Hampe; Laura Petrosini; Paola De Bartolo; Paola Caporali; Debora Cutuli; Daniela Laricchiuta; Francesca Foti; Jared R Radtke; Veronika Vidova; Jérôme Honnorat; Mario Manto
Journal:  Orphanet J Rare Dis       Date:  2013-06-05       Impact factor: 4.123

10.  An update on the cerebellar subtype of multiple system atrophy.

Authors:  Ludovico Ciolli; Florian Krismer; Ferdinando Nicoletti; Gregor K Wenning
Journal:  Cerebellum Ataxias       Date:  2014-10-10
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