Literature DB >> 7942859

The power of interval mapping of quantitative trait loci, using selected sib pairs.

L R Cardon1, D W Fulker.   

Abstract

The interval-mapping procedure of Fulker and Cardon for analysis of a quantitative-trait loci (QTL) is extended for application to selected samples of sib pairs. Phenotypic selection of sib pairs, which is known to yield striking increases in power when a single marker is used, provides further increases in power when the interval-mapping approach is used. The greatest benefits of the combined approach are apparent with coarse maps, where QTLs of relatively modest (15%-20%) heritability can be detected with widely spaced markers (40-60 cM apart) in reasonably sized sibling samples. Useful information concerning QTL location is afforded by interval mapping in both selected and unselected samples.

Mesh：

Year:  1994        PMID： 7942859      PMCID： PMC1918307     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  9 in total

1.  Multipoint analysis of human quantitative genetic variation.

Authors:  D E Goldgar
Journal:  Am J Hum Genet       Date:  1990-12       Impact factor: 11.025

2.  Linkage analysis of quantitative traits: increased power by using selected samples.

Authors:  G Carey; J Williamson
Journal:  Am J Hum Genet       Date:  1991-10       Impact factor: 11.025

3.  Mapping mendelian factors underlying quantitative traits using RFLP linkage maps.

Authors:  E S Lander; D Botstein
Journal:  Genetics       Date:  1989-01       Impact factor: 4.562

4.  A more powerful robust sib-pair test of linkage for quantitative traits.

Authors:  C I Amos; R C Elston; A F Wilson; J E Bailey-Wilson
Journal:  Genet Epidemiol       Date:  1989       Impact factor: 2.135

5.  Multiple regression analysis of twin data obtained from selected samples.

Authors:  M C LaBuda; J C DeFries; D W Fulker
Journal:  Genet Epidemiol       Date:  1986       Impact factor: 2.135

6.  Linkage between marker loci and those affecting a quantitative trait.

Authors:  A Robertson
Journal:  Behav Genet       Date:  1973-12       Impact factor: 2.805

7.  A sib-pair approach to interval mapping of quantitative trait loci.

Authors:  D W Fulker; L R Cardon
Journal:  Am J Hum Genet       Date:  1994-06       Impact factor: 11.025

8.  Multiple regression analysis of twin data.

Authors:  J C DeFries; D W Fulker
Journal:  Behav Genet       Date:  1985-09       Impact factor: 2.805

9.  The investigation of linkage between a quantitative trait and a marker locus.

Authors:  J K Haseman; R C Elston
Journal:  Behav Genet       Date:  1972-03       Impact factor: 2.805
  9 in total
  12 in total

1.  Transformation of sib-pair values for the Haseman-Elston method.

Authors:  D Wang; S Lin; R Cheng; X Gao; F A Wright
Journal:  Am J Hum Genet       Date:  2001-04-17       Impact factor: 11.025

2.  Reading disability: evidence for a genetic etiology.

Authors:  J Gayán; R K Olson
Journal:  Eur Child Adolesc Psychiatry       Date:  1999       Impact factor: 4.785

3.  The power to detect linkage disequilibrium with quantitative traits in selected samples.

Authors:  G R Abecasis; W O Cookson; L R Cardon
Journal:  Am J Hum Genet       Date:  2001-05-08       Impact factor: 11.025

4.  Linkage analysis of extremely discordant and concordant sibling pairs identifies quantitative-trait loci that influence variation in the human personality trait neuroticism.

Authors:  Jan Fullerton; Matthew Cubin; Hemant Tiwari; Chenxi Wang; Amarjit Bomhra; Stuart Davidson; Sue Miller; Christopher Fairburn; Guy Goodwin; Michael C Neale; Simon Fiddy; Richard Mott; David B Allison; Jonathan Flint
Journal:  Am J Hum Genet       Date:  2003-02-20       Impact factor: 11.025

5.  Evidence of linkage of HDL level variation to APOC3 in two samples with different ascertainment.

Authors:  France Gagnon; Gail P Jarvik; Arno G Motulsky; Samir S Deeb; John D Brunzell; Ellen M Wijsman
Journal:  Hum Genet       Date:  2003-08-29       Impact factor: 4.132

6.  Optimal designs for linkage disequilibrium mapping and candidate gene association tests in livestock populations.

Authors:  Alessandra Stella; Paul J Boettcher
Journal:  Genetics       Date:  2004-01       Impact factor: 4.562

7.  Using multivariate genetic modeling to detect pleiotropic quantitative trait loci.

Authors:  D I Boomsma
Journal:  Behav Genet       Date:  1996-03       Impact factor: 2.805

8.  A simulation study of the effects of assignment of prior identity-by-descent probabilities to unselected sib pairs, in covariance-structure modeling of a quantitative-trait locus.

Authors:  C V Dolan; D I Boomsma; M C Neale
Journal:  Am J Hum Genet       Date:  1999-01       Impact factor: 11.025

9.  Multipoint interval mapping of quantitative trait loci, using sib pairs.

Authors:  D W Fulker; S S Cherny; L R Cardon
Journal:  Am J Hum Genet       Date:  1995-05       Impact factor: 11.025

10.  Complete multipoint sib-pair analysis of qualitative and quantitative traits.

Authors:  L Kruglyak; E S Lander
Journal:  Am J Hum Genet       Date:  1995-08       Impact factor: 11.025
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