INTRODUCTION: The relationship between plasma levels of S-adenosylmethionine (SAMe), an endogenous methyl donor, and clinical response were studied in patients with a DSM-III-R diagnosis of major depression. MATERIAL AND METHODS: A double-blind randomized protocol comparing oral SAMe with oral desipramine, involving a total of 26 patients, was employed. RESULTS: At the end of the 4-week trial, 62% of the patients treated with SAMe and 50% of the patients treated with desipramine had significantly improved. Regardless of the type of treatment, patients with a 50% decrease in their Hamilton Depression Scale (HAM-D) score showed a significant increase in plasma SAMe concentration. CONCLUSION: The significant correlation between plasma SAMe levels and the degree of clinical improvement in depressed patients regardless of the type of treatment suggests that SAMe may play an important role in regulating mood.
RCT Entities:
INTRODUCTION: The relationship between plasma levels of S-adenosylmethionine (SAMe), an endogenous methyl donor, and clinical response were studied in patients with a DSM-III-R diagnosis of major depression. MATERIAL AND METHODS: A double-blind randomized protocol comparing oral SAMe with oral desipramine, involving a total of 26 patients, was employed. RESULTS: At the end of the 4-week trial, 62% of the patients treated with SAMe and 50% of the patients treated with desipramine had significantly improved. Regardless of the type of treatment, patients with a 50% decrease in their Hamilton Depression Scale (HAM-D) score showed a significant increase in plasma SAMe concentration. CONCLUSION: The significant correlation between plasma SAMe levels and the degree of clinical improvement in depressedpatients regardless of the type of treatment suggests that SAMe may play an important role in regulating mood.
Authors: Anup Sharma; Patricia Gerbarg; Teodoro Bottiglieri; Lila Massoumi; Linda L Carpenter; Helen Lavretsky; Philip R Muskin; Richard P Brown; David Mischoulon Journal: J Clin Psychiatry Date: 2017-06 Impact factor: 4.384
Authors: Izaskun Villar-Menéndez; Fabiana Nuñez; Sara Díaz-Sánchez; José Luis Albasanz; Jaume Taura; Víctor Fernández-Dueñas; Isidre Ferrer; Mairena Martín; Francisco Ciruela; Marta Barrachina Journal: Purinergic Signal Date: 2014-06-19 Impact factor: 3.765
Authors: Ilaria Galizia; Lucio Oldani; Karine Macritchie; Erica Amari; Dominic Dougall; Tessa N Jones; Raymond W Lam; Guido Jacopo Massei; Lakshmi N Yatham; Allan H Young Journal: Cochrane Database Syst Rev Date: 2016-10-10
Authors: Annick V Hartstra; Valentina Schüppel; Sultan Imangaliyev; Anouk Schrantee; Andrei Prodan; Didier Collard; Evgeni Levin; Geesje Dallinga-Thie; Mariette T Ackermans; Maaike Winkelmeijer; Stefan R Havik; Amira Metwaly; Ilias Lagkouvardos; Anika Nier; Ina Bergheim; Mathias Heikenwalder; Andreas Dunkel; Aart J Nederveen; Gerhard Liebisch; Giulia Mancano; Sandrine P Claus; Alfonso Benítez-Páez; Susanne E la Fleur; Jacques J Bergman; Victor Gerdes; Yolanda Sanz; Jan Booij; Elles Kemper; Albert K Groen; Mireille J Serlie; Dirk Haller; Max Nieuwdorp Journal: Mol Metab Date: 2020-09-08 Impact factor: 7.422