Literature DB >> 7941352

The 2A proteinase of human rhinovirus is a zinc containing enzyme.

W Sommergruber1, G Casari, F Fessl, J Seipelt, T Skern.   

Abstract

The 2A proteinase of human rhinovirus (HRV) 2 is a cysteine proteinase which is not inhibited by metal chelating agents. However, total hydrolysis of highly purified HRV2 2A followed by atom emission spectroscopy demonstrated that HRV2 2A contains 1 mol of zinc per mole of enzyme. Furthermore, Zn depletion of the enzyme led to a loss of proteolytic activity which could subsequently be restored by Zn supplementation.

Entities:  

Mesh：

Substances：

Year:  1994        PMID： 7941352     DOI： 10.1006/viro.1994.1599

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  17 in total

1.  A cysteine-rich motif in poliovirus protein 2C(ATPase) is involved in RNA replication and binds zinc in vitro.

Authors:  T Pfister; K W Jones; E Wimmer
Journal:  J Virol       Date:  2000-01       Impact factor: 5.103

2.  Identification of mouse hepatitis virus papain-like proteinase 2 activity.

Authors:  A Kanjanahaluethai; S C Baker
Journal:  J Virol       Date:  2000-09       Impact factor: 5.103

3.  Conformational stability of hepatitis C virus NS3 protease.

Authors:  Olga Abian; Sonia Vega; Jose Luis Neira; Adrian Velazquez-Campoy
Journal:  Biophys J       Date:  2010-12-01       Impact factor: 4.033

4.  Human rhinovirus 2A proteinase mutant and its second-site revertants.

Authors:  M Luderer-Gmach; H D Liebig; W Sommergruber; T Voss; F Fessl; T Skern; E Kuechler
Journal:  Biochem J       Date:  1996-08-15       Impact factor: 3.857

5.  The leader peptide of Theiler's murine encephalomyelitis virus is a zinc-binding protein.

Authors:  H H Chen; W P Kong; R P Roos
Journal:  J Virol       Date:  1995-12       Impact factor: 5.103

6.  Mengovirus leader is involved in the inhibition of host cell protein synthesis.

Authors:  J Zoll; J M Galama; F J van Kuppeveld; W J Melchers
Journal:  J Virol       Date:  1996-08       Impact factor: 5.103

7.  Translating ribosomes inhibit poliovirus negative-strand RNA synthesis.

Authors:  D J Barton; B J Morasco; J B Flanegan
Journal:  J Virol       Date:  1999-12       Impact factor: 5.103

8.  The NS3 proteinase domain of hepatitis C virus is a zinc-containing enzyme.

Authors:  M Stempniak; Z Hostomska; B R Nodes; Z Hostomsky
Journal:  J Virol       Date:  1997-04       Impact factor: 5.103

9.  The processing of eIF4GI by human rhinovirus type 2 2A(pro): relationship to self-cleavage and role of zinc.

Authors:  Walter Glaser; Andrea Triendl; Tim Skern
Journal:  J Virol       Date:  2003-04       Impact factor: 5.103

10.  Spectroscopic characterization of rhinoviral protease 2A: Zn is essential for the structural integrity.

Authors:  T Voss; R Meyer; W Sommergruber
Journal:  Protein Sci       Date:  1995-12       Impact factor: 6.725
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.