Literature DB >> 7494325

The leader peptide of Theiler's murine encephalomyelitis virus is a zinc-binding protein.

H H Chen1, W P Kong, R P Roos.   

Abstract

The leader (L) peptide is located in the amino-terminal part of the polyprotein of members of the Cardiovirus (which includes Theiler's murine encephalomyelitis virus) and Aphthovirus genera of picornaviruses. Although the function of L is unknown, strain DA of Theiler's murine encephalomyelitis virus with a mutation of L produces a cell-specific restricted infection. We now report that the DA L peptide is a metalloprotein and that zinc binds to a Cys-His motif that is conserved among cardioviruses.

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Year:  1995        PMID： 7494325      PMCID： PMC189757     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  18 in total

1.  Specificity of enzyme-substrate interactions in foot-and-mouth disease virus polyprotein processing.

Authors:  M D Ryan; G J Belsham; A M King
Journal:  Virology       Date:  1989-11       Impact factor: 3.616

Review 2.  Zinc proteins: enzymes, storage proteins, transcription factors, and replication proteins.

Authors:  J E Coleman
Journal:  Annu Rev Biochem       Date:  1992       Impact factor: 23.643

3.  Characterization of functional HPV-16 E7 protein produced in Escherichia coli.

Authors:  D R Patrick; K Zhang; D Defeo-Jones; G R Vuocolo; R Z Maigetter; M K Sardana; A Oliff; D C Heimbrook
Journal:  J Biol Chem       Date:  1992-04-05       Impact factor: 5.157

4.  Papillomavirus polypeptides E6 and E7 are zinc-binding proteins.

Authors:  M S Barbosa; D R Lowy; J T Schiller
Journal:  J Virol       Date:  1989-03       Impact factor: 5.103

5.  Leader protein of foot-and-mouth disease virus is required for cleavage of the p220 component of the cap-binding protein complex.

Authors:  M A Devaney; V N Vakharia; R E Lloyd; E Ehrenfeld; M J Grubman
Journal:  J Virol       Date:  1988-11       Impact factor: 5.103

6.  A retrovirus-like zinc domain is essential for translational repression of bacteriophage T4 gene 32.

Authors:  Y Shamoo; K R Webster; K R Williams; W H Konigsberg
Journal:  J Biol Chem       Date:  1991-05-05       Impact factor: 5.157

7.  Characterization of a zinc blotting technique: evidence that a retroviral gag protein binds zinc.

Authors:  L A Schiff; M L Nibert; B N Fields
Journal:  Proc Natl Acad Sci U S A       Date:  1988-06       Impact factor: 11.205

8.  Molecular cloning and sequence determination of DA strain of Theiler's murine encephalomyelitis viruses.

Authors:  Y Ohara; S Stein; J L Fu; L Stillman; L Klaman; R P Roos
Journal:  Virology       Date:  1988-05       Impact factor: 3.616

9.  Characterization of the roles of conserved cysteine and histidine residues in poliovirus 2A protease.

Authors:  S F Yu; R E Lloyd
Journal:  Virology       Date:  1992-02       Impact factor: 3.616

10.  Conserved tertiary structure elements in the 5' untranslated region of human enteroviruses and rhinoviruses.

Authors:  S Y Le; J H Chen; N Sonenberg; J V Maizel
Journal:  Virology       Date:  1992-12       Impact factor: 3.616
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  33 in total

1.  A cysteine-rich motif in poliovirus protein 2C(ATPase) is involved in RNA replication and binds zinc in vitro.

Authors:  T Pfister; K W Jones; E Wimmer
Journal:  J Virol       Date:  2000-01       Impact factor: 5.103

2.  The leader polypeptide of Theiler's murine encephalomyelitis virus is required for the assembly of virions in mouse L cells.

Authors:  C Badshah; M A Calenoff; K Rundell
Journal:  J Virol       Date:  2000-01       Impact factor: 5.103

3.  The mengovirus leader protein suppresses alpha/beta interferon production by inhibition of the iron/ferritin-mediated activation of NF-kappa B.

Authors:  Jan Zoll; Willem J G Melchers; Jochem M D Galama; Frank J M van Kuppeveld
Journal:  J Virol       Date:  2002-10       Impact factor: 5.103

4.  The leader protein of Theiler's virus interferes with nucleocytoplasmic trafficking of cellular proteins.

Authors:  Sophie Delhaye; Vincent van Pesch; Thomas Michiels
Journal:  J Virol       Date:  2004-04       Impact factor: 5.103

5.  Different strains of Theiler's murine encephalomyelitis virus antagonize different sites in the type I interferon pathway.

Authors:  Spyridon Stavrou; Zongdi Feng; Stanley M Lemon; Raymond P Roos
Journal:  J Virol       Date:  2010-07-07       Impact factor: 5.103

6.  Different subcellular localization of Theiler's murine encephalomyelitis virus leader proteins of GDVII and DA strains in BHK-21 cells.

Authors:  Naoko Taniura; Mineki Saito; Takako Okuwa; Kousuke Saito; Yoshiro Ohara
Journal:  J Virol       Date:  2009-04-22       Impact factor: 5.103

7.  Complete genome analysis of three novel picornaviruses from diverse bat species.

Authors:  Susanna K P Lau; Patrick C Y Woo; Kenneth K Y Lai; Yi Huang; Cyril C Y Yip; Chung-Tong Shek; Paul Lee; Carol S F Lam; Kwok-Hung Chan; Kwok-Yung Yuen
Journal:  J Virol       Date:  2011-06-22       Impact factor: 5.103

8.  Revertant analysis of J-K mutations in the encephalomyocarditis virus internal ribosomal entry site detects an altered leader protein.

Authors:  M A Hoffman; A C Palmenberg
Journal:  J Virol       Date:  1996-09       Impact factor: 5.103

9.  Protein 2A is not required for Theiler's virus replication.

Authors:  T Michiels; V Dejong; R Rodrigus; C Shaw-Jackson
Journal:  J Virol       Date:  1997-12       Impact factor: 5.103

10.  The polypyrimidine tract binding protein (PTB) requirement for internal initiation of translation of cardiovirus RNAs is conditional rather than absolute.

Authors:  A Kaminski; R J Jackson
Journal:  RNA       Date:  1998-06       Impact factor: 4.942
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