Literature DB >> 7937797

Cerebrodiene: a brain lipid isolated from sleep-deprived cats.

R A Lerner1, G Siuzdak, O Prospero-Garcia, S J Henriksen, D L Boger, B F Cravatt.   

Abstract

We report the isolation of a heretofore unrecognized brain lipid that is present in cerebrospinal fluid of sleep-deprived cats. The molecule appears to be a long-chain base structurally related to sphingosine and sphinganine in which a second unsaturated bond has been introduced. An increase in the degree of unsaturation of a key membrane component is expected to have important physiological consequences.

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Year:  1994        PMID： 7937797      PMCID： PMC44841          DOI： 10.1073/pnas.91.20.9505

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  7 in total

Review 1.  The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling.

Authors:  R Kolesnick; D W Golde
Journal:  Cell       Date:  1994-05-06       Impact factor: 41.582

Review 2.  Lipid second messengers.

Authors:  M Liscovitch; L C Cantley
Journal:  Cell       Date:  1994-05-06       Impact factor: 41.582

Review 3.  The sphingomyelin cycle and the second messenger function of ceramide.

Authors:  Y A Hannun
Journal:  J Biol Chem       Date:  1994-02-04       Impact factor: 5.157

4.  Acetonitrile-hydrochloric acid hydrolysis of gangliosides for high performance liquid chromatographic analysis of their long chain bases.

Authors:  H Kadowaki; E G Bremer; J E Evans; F B Jungalwala; R H McCluer
Journal:  J Lipid Res       Date:  1983-10       Impact factor: 5.922

5.  Selectivity of ceramide-mediated biology. Lack of activity of erythro-dihydroceramide.

Authors:  A Bielawska; H M Crane; D Liotta; L M Obeid; Y A Hannun
Journal:  J Biol Chem       Date:  1993-12-15       Impact factor: 5.157

Review 6.  Functions of sphingolipids and sphingolipid breakdown products in cellular regulation.

Authors:  Y A Hannun; R M Bell
Journal:  Science       Date:  1989-01-27       Impact factor: 47.728

7.  Control of fatty acid composition in phospholipids of Escherichia coli: response to fatty acid supplements in a fatty acid auxotroph.

Authors:  M Esfahani; E M Barnes; S J Wakil
Journal:  Proc Natl Acad Sci U S A       Date:  1969-11       Impact factor: 11.205
  7 in total
  26 in total

Review 1.  A hypothesis about the endogenous analogue of general anesthesia.

Authors:  R A Lerner
Journal:  Proc Natl Acad Sci U S A       Date:  1997-12-09       Impact factor: 11.205

2.  Chemical requirements for inhibition of gap junction communication by the biologically active lipid oleamide.

Authors:  D L Boger; J E Patterson; X Guan; B F Cravatt; R A Lerner; N B Gilula
Journal:  Proc Natl Acad Sci U S A       Date:  1998-04-28       Impact factor: 11.205

3.  Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide.

Authors:  D L Boger; H Sato; A E Lerner; M P Hedrick; R A Fecik; H Miyauchi; G D Wilkie; B J Austin; M P Patricelli; B F Cravatt
Journal:  Proc Natl Acad Sci U S A       Date:  2000-05-09       Impact factor: 11.205

Review 4.  Fatty acid amide signaling molecules.

Authors:  Cyrine Ezzili; Katerina Otrubova; Dale L Boger
Journal:  Bioorg Med Chem Lett       Date:  2010-08-13       Impact factor: 2.823

Review 5.  The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH).

Authors:  Katerina Otrubova; Cyrine Ezzili; Dale L Boger
Journal:  Bioorg Med Chem Lett       Date:  2011-06-28       Impact factor: 2.823

Review 6.  The emergence of mass spectrometry in biochemical research.

Authors:  G Siuzdak
Journal:  Proc Natl Acad Sci U S A       Date:  1994-11-22       Impact factor: 11.205

7.  Fluoride-mediated capture of a noncovalent bound state of a reversible covalent enzyme inhibitor: X-ray crystallographic analysis of an exceptionally potent α-ketoheterocycle inhibitor of fatty acid amide hydrolase.

Authors:  Mauro Mileni; Joie Garfunkle; Cyrine Ezzili; Benjamin F Cravatt; Raymond C Stevens; Dale L Boger
Journal:  J Am Chem Soc       Date:  2011-02-28       Impact factor: 15.419

8.  Rational design of fatty acid amide hydrolase inhibitors that act by covalently bonding to two active site residues.

Authors:  Katerina Otrubova; Monica Brown; Michael S McCormick; Gye W Han; Scott T O'Neal; Benjamin F Cravatt; Raymond C Stevens; Aron H Lichtman; Dale L Boger
Journal:  J Am Chem Soc       Date:  2013-04-12       Impact factor: 15.419

9.  X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase.

Authors:  Mauro Mileni; Joie Garfunkle; Cyrine Ezzili; F Scott Kimball; Benjamin F Cravatt; Raymond C Stevens; Dale L Boger
Journal:  J Med Chem       Date:  2010-01-14       Impact factor: 7.446

10.  Discovery libraries targeting the major enzyme classes: the serine hydrolases.

Authors:  Katerina Otrubova; Venkat Srinivasan; Dale L Boger
Journal:  Bioorg Med Chem Lett       Date:  2014-06-27       Impact factor: 2.823
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