Literature DB >> 7928627

Gastrin receptor gene expression in several human carcinomas.

Y Matsushima1, Y Kinoshita, H Nakata, Y Inomoto-Naribayashi, M Asahara, C Kawanami, A Nakamura, M Ito, T Matsui, T Fujiwara.   

Abstract

Gastrin has been shown to enhance the growth of various human tumors. The present study was designed to examine the gastrin receptor gene expression in various human carcinoma cell lines and in surgically resected carcinoma tissues. By Northern blot analysis, gastrin receptor mRNA was detected in 3 out of 7 small cell lung carcinoma cell lines. Gastrin receptor mRNA was also expressed in one out of 8 colon carcinoma cell lines and 2 out of 10 colon carcinoma tissues. Moreover, one of two small cell carcinoma cell lines of the stomach clearly expressed gastrin receptor mRNA. However, none of the gastric adenocarcinoma cell lines or surgically resected gastric adenocarcinomas tested had any detectable expression of gastrin receptor gene. These findings may suggest a role of gastrin receptor in the growth and differentiation of certain human carcinomas.

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Year:  1994        PMID： 7928627      PMCID： PMC5919565          DOI： 10.1111/j.1349-7006.1994.tb02953.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  31 in total

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Journal:  Gastroenterology       Date:  1993-08       Impact factor: 22.682

6.  Evidence for autocrine growth stimulation of cultured colon tumor cells by a gastrin/cholecystokinin-like peptide.

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Journal:  Exp Cell Res       Date:  1990-01       Impact factor: 3.905

7.  Characterization of four new cell lines derived from small-cell gastrointestinal carcinoma.

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Journal:  Int J Cancer       Date:  1993-07-30       Impact factor: 7.396

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9.  Altered expression of the retinoblastoma (RB) gene in small-cell carcinoma of the lung.

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Authors:  O E Winsett; C M Townsend; E J Glass; J C Thompson
Journal:  Surgery       Date:  1986-03       Impact factor: 3.982
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  9 in total

1.  Expression of gastrin, gastrin/CCK-B and gastrin/CCK-C receptors in human colorectal carcinomas.

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2.  Omeprazole tolerability.

Authors:  H L Waldum; E Brenna
Journal:  Drug Saf       Date:  1994-12       Impact factor: 5.606

3.  Long-term effects of proglumide on resection of cardiac adenocarcinoma.

Authors:  Yu-Ping Chen; Jie-Sheng Yang; Di-Tian Liu; Wei-Ping Yang
Journal:  World J Gastroenterol       Date:  2005-05-07       Impact factor: 5.742

4.  A comparison of the therapeutic effectiveness of gastrin neutralisation in two human gastric cancer models: relation to endocrine and autocrine/paracrine gastrin mediated growth.

Authors:  S A Watson; T M Morris; A Varro; D Michaeli; A M Smith
Journal:  Gut       Date:  1999-12       Impact factor: 23.059

5.  Gastrin and gastrin receptor activation: an early event in the adenoma-carcinoma sequence.

Authors:  A M Smith; S A Watson
Journal:  Gut       Date:  2000-12       Impact factor: 23.059

Review 6.  Gastrin, gastrin receptors and colorectal carcinoma.

Authors:  G S Baldwin; A Shulkes
Journal:  Gut       Date:  1998-04       Impact factor: 23.059

7.  Coexpression of gastrin and gastrin receptors (CCK-B and delta CCK-B) in gastrointestinal tumour cell lines.

Authors:  D F McWilliams; S A Watson; D M Crosbee; D Michaeli; R Seth
Journal:  Gut       Date:  1998-06       Impact factor: 23.059

8.  The role of endogenous gastrin in the development of enterochromaffin-like cell carcinoid tumors in Mastomys natalensis: a study with the specific gastrin receptor antagonist AG-041R.

Authors:  T Chiba; Y Kinoshita; M Sawada; K Kishi; A Baba; E Hoshino
Journal:  Yale J Biol Med       Date:  1998 May-Aug

Review 9.  Gastrin, Cholecystokinin, Signaling, and Biological Activities in Cellular Processes.

Authors:  Qiang Zeng; Lei Ou; Wei Wang; Dong-Yu Guo
Journal:  Front Endocrinol (Lausanne)       Date:  2020-03-06       Impact factor: 5.555
  9 in total

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