Literature DB >> 7922783

Human recombinant interleukin-1 receptor antagonist blocks bone resorption induced by interleukin-1 beta but not interleukin-1 alpha.

R A Chole1, S P Tinling, B T Faddis.   

Abstract

Both interleukin-1 alpha (IL-1 alpha) and interleukin-1 beta (IL-1 beta) are powerful stimulators of bone resorption in vivo and in vitro. Interleukin-1 receptor antagonist (IL-1ra) binds to many interleukin-1 receptors. It does not activate the receptor and effectively blocks the action of IL-1 alpha and IL-1 beta. In this study, human recombinant IL-1ra, at 100-fold excess, was found to block bone resorption in cultured mouse calvaria due to IL-1 beta but not IL-1 alpha. These observations may be explained by differential affinities of receptors for IL-1 alpha, IL-1 beta and rhIL-1ra on target bone cells.

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Year:  1994        PMID： 7922783     DOI： 10.1007/bf00310162

Source DB:  PubMed          Journal:  Calcif Tissue Int        ISSN： 0171-967X            Impact factor:   4.333


  34 in total

1.  Two high-affinity interleukin 1 receptors represent separate gene products.

Authors:  R Chizzonite; T Truitt; P L Kilian; A S Stern; P Nunes; K P Parker; K L Kaffka; A O Chua; D K Lugg; U Gubler
Journal:  Proc Natl Acad Sci U S A       Date:  1989-10       Impact factor: 11.205

2.  A soluble binding protein specific for interleukin 1 beta is produced by activated mononuclear cells.

Authors:  J A Symons; J A Eastgate; G W Duff
Journal:  Cytokine       Date:  1990-05       Impact factor: 3.861

3.  Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein.

Authors:  D B Carter; M R Deibel; C J Dunn; C S Tomich; A L Laborde; J L Slightom; A E Berger; M J Bienkowski; F F Sun; R N McEwan
Journal:  Nature       Date:  1990-04-12       Impact factor: 49.962

4.  Effects of interleukin-1 receptor antagonist on three types of responses to interleukin-1 in rabbit isolated blood vessels.

Authors:  E Petitclerc; S Abel; D deBlois; P E Poubelle; F Marceau
Journal:  J Cardiovasc Pharmacol       Date:  1992-05       Impact factor: 3.105

5.  Recombinant interleukin-1 receptor antagonist (IL-1ra): effective therapy against gram-negative sepsis in rats.

Authors:  H R Alexander; G M Doherty; D J Venzon; M J Merino; D L Fraker; J A Norton
Journal:  Surgery       Date:  1992-08       Impact factor: 3.982

6.  An interleukin 1 like factor stimulates bone resorption in vitro.

Authors:  M Gowen; D D Wood; E J Ihrie; M K McGuire; R G Russell
Journal:  Nature       Date:  1983 Nov 24-30       Impact factor: 49.962

7.  Interleukin-1 beta stimulates bone resorption and inhibits bone formation in vivo.

Authors:  L Nguyen; F E Dewhirst; P V Hauschka; P Stashenko
Journal:  Lymphokine Cytokine Res       Date:  1991-04

8.  Bone-resorbing agents promote and interferon-gamma inhibits bone cell collagenase production.

Authors:  V Shen; G Kohler; J J Jeffrey; W A Peck
Journal:  J Bone Miner Res       Date:  1988-12       Impact factor: 6.741

9.  Interleukin-1 receptor antagonist inhibits the hypercalcemia mediated by interleukin-1.

Authors:  T A Guise; I R Garrett; L F Bonewald; G R Mundy
Journal:  J Bone Miner Res       Date:  1993-05       Impact factor: 6.741

10.  Detection and characterization of high affinity plasma membrane receptors for human interleukin 1.

Authors:  S K Dower; S R Kronheim; C J March; P J Conlon; T P Hopp; S Gillis; D L Urdal
Journal:  J Exp Med       Date:  1985-08-01       Impact factor: 14.307
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