| Literature DB >> 2139180 |
D B Carter1, M R Deibel, C J Dunn, C S Tomich, A L Laborde, J L Slightom, A E Berger, M J Bienkowski, F F Sun, R N McEwan.
Abstract
A human myelomonocytic cell line, U937, produced an interleukin-1 (IL-1) receptor antagonist protein (IRAP) which was purified and partially sequenced. A complementary DNA coding for IRAP was cloned and sequenced. The mature translation product of the cDNA has been expressed in Escherichia coli and was an active competitive inhibitor of the binding of IL-1 to the T-cell/fibroblast form of the IL-1 receptor. Recombinant IRAP specifically inhibited IL-1 bioactivity on T cells and endothelial cells in vitro and was a potent inhibitor of IL-1 induced corticosterone production in vivo.Entities:
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Year: 1990 PMID： 2139180 DOI： 10.1038/344633a0
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962