Literature DB >> 7922037

Structure-based drug design: progress, results and challenges.

C L Verlinde1, W G Hol.   

Abstract

Protein structure-based drug design is rapidly gaining momentum. The new opportunities, developments and results in this field are almost unbelievable compared with the situation less than a decade ago.

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Year:  1994        PMID： 7922037     DOI： 10.1016/s0969-2126(00)00060-5

Source DB:  PubMed          Journal:  Structure        ISSN： 0969-2126            Impact factor:   5.006


  32 in total

1.  Scoring functions: a view from the bench.

Authors:  J R Tame
Journal:  J Comput Aided Mol Des       Date:  1999-03       Impact factor: 3.686

2.  Identification of ligands for RNA targets via structure-based virtual screening: HIV-1 TAR.

Authors:  A V Filikov; V Mohan; T A Vickers; R H Griffey; P D Cook; R A Abagyan; T L James
Journal:  J Comput Aided Mol Des       Date:  2000-08       Impact factor: 3.686

3.  Evaluation of designed ligands by a multiple screening method: application to glycogen phosphorylase inhibitors constructed with a variety of approaches.

Authors:  S S So; M Karplus
Journal:  J Comput Aided Mol Des       Date:  2001-07       Impact factor: 3.686

4.  Further development and validation of empirical scoring functions for structure-based binding affinity prediction.

Authors:  Renxiao Wang; Luhua Lai; Shaomeng Wang
Journal:  J Comput Aided Mol Des       Date:  2002-01       Impact factor: 3.686

5.  Network-based selectivity of antiparasitic inhibitors.

Authors:  Barbara M Bakker; Heike E Assmus; Frank Bruggeman; Jurgen R Haanstra; Edda Klipp; Hans Westerhoff
Journal:  Mol Biol Rep       Date:  2002       Impact factor: 2.316

Review 6.  Class-directed structure determination: foundation for a protein structure initiative.

Authors:  T C Terwilliger; G Waldo; T S Peat; J M Newman; K Chu; J Berendzen
Journal:  Protein Sci       Date:  1998-09       Impact factor: 6.725

7.  A branch-and-bound method for optimal atom-type assignment in de novo ligand design.

Authors:  N P Todorov; P M Dean
Journal:  J Comput Aided Mol Des       Date:  1998-07       Impact factor: 3.686

8.  PRO_SELECT: combining structure-based drug design and combinatorial chemistry for rapid lead discovery. 1. Technology.

Authors:  C W Murray; D E Clark; T R Auton; M A Firth; J Li; R A Sykes; B Waszkowycz; D R Westhead; S C Young
Journal:  J Comput Aided Mol Des       Date:  1997-03       Impact factor: 3.686

9.  Evaluation of a method for controlling molecular scaffold diversity in de novo ligand design.

Authors:  N P Todorov; P M Dean
Journal:  J Comput Aided Mol Des       Date:  1997-03       Impact factor: 3.686

10.  Development of simple fitness landscapes for peptides by artificial neural filter systems.

Authors:  G Schneider; J Schuchhardt; P Wrede
Journal:  Biol Cybern       Date:  1995-08       Impact factor: 2.086
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