Literature DB >> 7920662

High resolution localization of recombination hot spots using sperm typing.

R Hubert1, M MacDonald, J Gusella, N Arnheim.   

Abstract

We have applied sperm DNA typing to determine the distribution of crossover events within a one megabase region of the short arm of human chromosome 4 near the locus for Huntington disease. A total of 29 recombinants were detected among 602 sperm typed after whole genome amplification. These recombinants were typed for seven polymorphic markers. The 280 kilobase D4S10-D4S126 interval was found to undergo recombination at a 6-9-fold greater rate per unit of physical distance than the adjacent 720 kb D4S126-D4S127 interval. Sperm typing has the potential to dissect mammalian recombination hot spots to the point where DNA sequence analysis may reveal the molecular basis for hyperrecombination.

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Year:  1994        PMID： 7920662     DOI： 10.1038/ng0794-420

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  31 in total

Review 1.  Hot and cold spots of recombination in the human genome: the reason we should find them and how this can be achieved.

Authors:  Norman Arnheim; Peter Calabrese; Magnus Nordborg
Journal:  Am J Hum Genet       Date:  2003-05-22       Impact factor: 11.025

2.  Positive selection can create false hotspots of recombination.

Authors:  Floyd A Reed; Sarah A Tishkoff
Journal:  Genetics       Date:  2005-12-30       Impact factor: 4.562

3.  High-resolution patterns of meiotic recombination across the human major histocompatibility complex.

Authors:  Michael Cullen; Stephen P Perfetto; William Klitz; George Nelson; Mary Carrington
Journal:  Am J Hum Genet       Date:  2002-09-23       Impact factor: 11.025

4.  High-resolution linkage map for two honeybee chromosomes: the hotspot quest.

Authors:  Florence Mougel; Marie-Anne Poursat; Nicolas Beaume; Dominique Vautrin; Michel Solignac
Journal:  Mol Genet Genomics       Date:  2013-10-27       Impact factor: 3.291

5.  Fraction of informative recombinations: a heuristic approach to analyze recombination rates.

Authors:  J-F Lefebvre; D Labuda
Journal:  Genetics       Date:  2008-04       Impact factor: 4.562

6.  Isolation of meiotic recombinants from mouse sperm.

Authors:  Francesca Cole; Maria Jasin
Journal:  Methods Mol Biol       Date:  2011

7.  Population-Specific Recombination Maps from Segments of Identity by Descent.

Authors:  Ying Zhou; Brian L Browning; Sharon R Browning
Journal:  Am J Hum Genet       Date:  2020-06-12       Impact factor: 11.025

8.  Dissecting genomic diversity, one cell at a time.

Authors:  Paul C Blainey; Stephen R Quake
Journal:  Nat Methods       Date:  2014-01       Impact factor: 28.547

9.  Product length, dye choice, and detection chemistry in the bead-emulsion amplification of millions of single DNA molecules in parallel.

Authors:  Irene Tiemann-Boege; Christina Curtis; Deepali N Shinde; Daniel B Goodman; Simon Tavaré; Norman Arnheim
Journal:  Anal Chem       Date:  2009-07-15       Impact factor: 6.986

10.  Genetic crossovers are predicted accurately by the computed human recombination map.

Authors:  Pavel P Khil; R Daniel Camerini-Otero
Journal:  PLoS Genet       Date:  2010-01-29       Impact factor: 5.917
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