| Literature DB >> 7920628 |
T Shirakawa1, A Li, M Dubowitz, J W Dekker, A E Shaw, J A Faux, C Ra, W O Cookson, J M Hopkin.
Abstract
The beta-subunit of the high-affinity IgE receptor (Fc epsilon RI-beta) on chromosome 11 is maternally linked to atopy, the state of enhanced IgE responsiveness underlying allergic asthma and rhinitis. We have identified a common variant of Fc epsilon RI-beta, lle181Leu within the 4th transmembrane domain. Leu181 shows significant association with positive IgE responses in a random patient sample. Amongst 60 unrelated nuclear families with allergic asthmatic probands, Leu181 is identified in 10 (17%), is maternally inherited in each, and shows a strong association with atopy. Our data indicate that Fc epsilon RI-beta, subject to maternal modification, may be the atopy-causing locus on chromosome 11q.Entities:
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Year: 1994 PMID： 7920628 DOI： 10.1038/ng0694-125
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330