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Literature DB >> 10343636

Genetics and pulmonary medicine 8: asthma.

Abstract

The field of asthma genetics has evolved in a markedly short time into a research field which potentially can provide a new level of understanding on the pathophysiology of the disease. There is consensus over a number of candidate genes that are likely to be important in the disease and also in chromosomal regions likely to contain other novel genes. It is, however, clear that there is no single major genetic risk factor for the development of asthma and the development of the disease in an individual will depend upon the interaction of a number of genes of moderate effect with environmental factors.

Entities: Disease

Mesh：

Substances：

Year: 1999 PMID： 10343636 PMCID： PMC1745345 DOI： 10.1136/thx.54.1.65

Source DB: PubMed Journal: Thorax ISSN： 0040-6376 Impact factor: 9.139

31 in total

1. The glutamine 27 beta2-adrenoceptor polymorphism is associated with elevated IgE levels in asthmatic families.

Authors: J C Dewar; J Wilkinson; A Wheatley; N S Thomas; I Doull; N Morton; P Lio; J F Harvey; S B Liggett; S T Holgate; I P Hall
Journal: J Allergy Clin Immunol Date: 1997-08 Impact factor: 10.793

Review 2. Genetics and pulmonary medicine. 1. The genetics of cystic fibrosis lung disease.

Authors: D J Davidson; D J Porteous
Journal: Thorax Date: 1998-05 Impact factor: 9.139

3. Asthma genetics: waiting to exhale.

Authors: S T Holgate
Journal: Nat Genet Date: 1997-03 Impact factor: 38.330

4. Linkage between immunoglobulin E responses underlying asthma and rhinitis and chromosome 11q.

Authors: W O Cookson; P A Sharp; J A Faux; J M Hopkin
Journal: Lancet Date: 1989-06-10 Impact factor: 79.321

5. High serum IgE concentrations: association with HLA-DR and markers on chromosome 5q31 and chromosome 11q13.

Authors: M Ulbrecht; T Eisenhut; J Bönisch; R Kruse; M Wjst; J Heinrich; H E Wichmann; E H Weiss; E D Albert
Journal: J Allergy Clin Immunol Date: 1997-06 Impact factor: 10.793

6. Genetic linkage of T-cell receptor alpha/delta complex to specific IgE responses.

Authors: M F Moffatt; M R Hill; F Cornélis; C Schou; J A Faux; R P Young; A L James; G Ryan; P le Souef; A W Musk
Journal: Lancet Date: 1994-06-25 Impact factor: 79.321

7. Naturally occurring mutations in the human 5-lipoxygenase gene promoter that modify transcription factor binding and reporter gene transcription.

Authors: K H In; K Asano; D Beier; J Grobholz; P W Finn; E K Silverman; E S Silverman; T Collins; A R Fischer; T P Keith; K Serino; S W Kim; G T De Sanctis; C Yandava; A Pillari; P Rubin; J Kemp; E Israel; W Busse; D Ledford; J J Murray; A Segal; D Tinkleman; J M Drazen
Journal: J Clin Invest Date: 1997-03-01 Impact factor: 14.808

Genetics and pulmonary medicine 8: asthma.

1. The glutamine 27 beta2-adrenoceptor polymorphism is associated with elevated IgE levels in asthmatic families.

Review 2. Genetics and pulmonary medicine. 1. The genetics of cystic fibrosis lung disease.

3. Asthma genetics: waiting to exhale.

4. Linkage between immunoglobulin E responses underlying asthma and rhinitis and chromosome 11q.

5. High serum IgE concentrations: association with HLA-DR and markers on chromosome 5q31 and chromosome 11q13.

6. Genetic linkage of T-cell receptor alpha/delta complex to specific IgE responses.

7. Naturally occurring mutations in the human 5-lipoxygenase gene promoter that modify transcription factor binding and reporter gene transcription.

8. Tumour necrosis factor haplotypes and asthma.

9. Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations.

10. Association between atopy and variants of the beta subunit of the high-affinity immunoglobulin E receptor.

Review 1. Complex interactions in complex traits: obesity and asthma.

2. Association of beta(2)-adrenergic receptor gene polymorphisms and nocturnal asthma in Saudi patients.