Literature DB >> 7919949

Determination of the backbone torsion angle epsilon in nucleic acids.

M J Blommers1, D Nanz, O Zerbe.   

Abstract

The multiplet structure of cross peaks in double-quantum-filtered COSY NMR spectra is analysed for those resonances that include passive heteronuclear couplings. Interestingly, the cross peak involving the sugar-ring protons H2' and H3' in nucleic acids display an E. COSY-type appearance exclusively when the backbone torsion angle epsilon (C4'-C3'-O3'-P) adopts a gauche(-) conformation. This observation allows an unambiguous analysis of the conformation around epsilon, without the knowledge of 3JCP coupling constants.

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Year:  1994        PMID： 7919949     DOI： 10.1007/bf00404271

Source DB:  PubMed          Journal:  J Biomol NMR        ISSN： 0925-2738            Impact factor:   2.835


  8 in total

Review 1.  Nucleic acids and nuclear magnetic resonance.

Authors:  F J Van de Ven; C W Hilbers
Journal:  Eur J Biochem       Date:  1988-12-01

2.  Restrained refinement of the monoclinic form of yeast phenylalanine transfer RNA. Temperature factors and dynamics, coordinated waters, and base-pair propeller twist angles.

Authors:  E Westhof; M Sundaralingam
Journal:  Biochemistry       Date:  1986-08-26       Impact factor: 3.162

3.  Determination of heteronuclear long-range couplings to heteronuclei in natural abundance by two- and three-dimensional NMR spectroscopy.

Authors:  P Schmieder; M Kurz; H Kessler
Journal:  J Biomol NMR       Date:  1991-11       Impact factor: 2.835

4.  The solution structure of the circular trinucleotide cr(GpGpGp) determined by NMR and molecular mechanics calculation.

Authors:  M M Mooren; S S Wijmenga; G A van der Marel; J H van Boom; C W Hilbers
Journal:  Nucleic Acids Res       Date:  1994-07-11       Impact factor: 16.971

5.  The three-dimensional structure of a DNA hairpin in solution two-dimensional NMR studies and structural analysis of d(ATCCTATTTATAGGAT).

Authors:  M J Blommers; F J van de Ven; G A van der Marel; J H van Boom; C W Hilbers
Journal:  Eur J Biochem       Date:  1991-10-01

6.  Effects of the introduction of L-nucleotides into DNA. Solution structure of the heterochiral duplex d(G-C-G-(L)T-G-C-G).d(C-G-C-A-C-G-C) studied by NMR spectroscopy.

Authors:  M J Blommers; L Tondelli; A Garbesi
Journal:  Biochemistry       Date:  1994-06-28       Impact factor: 3.162

7.  Solution structure of the 3'-5' cyclic dinucleotide d(pApA). A combined NMR, UV melting, and molecular mechanics study.

Authors:  M J Blommers; C A Haasnoot; J A Walters; G A van der Marel; J H van Boom; C W Hilbers
Journal:  Biochemistry       Date:  1988-11-01       Impact factor: 3.162

8.  Carbon-13 NMR in conformational analysis of nucleic acid fragments. 2. A reparametrization of the Karplus equation for vicinal NMR coupling constants in CCOP and HCOP fragments.

Authors:  P P Lankhorst; C A Haasnoot; C Erkelens; C Altona
Journal:  J Biomol Struct Dyn       Date:  1984-06
  8 in total
  2 in total

1.  Conformation of the circular dumbbell d<pCGC-TT-GCG-TT>: structure determination and molecular dynamics.

Authors:  J H Ippel; V Lanzotti; A Galeone; L Mayol; J E van den Boogaart; J A Pikkemaat; C Altona
Journal:  J Biomol NMR       Date:  1995-12       Impact factor: 2.835

2.  Structural study of DNA duplex containing an N-(2-deoxy-beta-D-erythro-pentofuranosyl) formamide frameshift by NMR and restrained molecular dynamics.

Authors:  C Maufrais; G V Fazakerley; J Cadet; Y Boulard
Journal:  Nucleic Acids Res       Date:  2003-10-15       Impact factor: 16.971
  2 in total

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