R D Bates1, M C Nahata. 1. Ohio State University, Wexner Institute for Pediatric Research, Columbus.
Abstract
OBJECTIVE: To provide an overview of the efficacy and adverse effects associated with once-daily administration of aminoglycosides. DATA SOURCES: An extensive MEDLINE search and review of journals was conducted to identify information for this review. DATA SYNTHESIS: Aminoglycosides alone or in combination with beta-lactams are commonly used for their activity against gram-negative microorganisms. Numerous studies have been performed comparing efficacy and toxicity of once-daily administration of aminoglycosides with multiple-daily dosing. Two studies have found a significant difference in clinical efficacy between once-daily and multiple-daily dosing of aminoglycosides. Several studies have observed a lower incidence of toxicity with once-daily than multiple-daily dosing, but others have found no difference. CONCLUSIONS: Review of the literature suggests that once-daily administration of aminoglycosides may be as safe and effective as multiple-daily dosing regimens for the treatment of certain infections caused by gram-negative bacteria.
OBJECTIVE: To provide an overview of the efficacy and adverse effects associated with once-daily administration of aminoglycosides. DATA SOURCES: An extensive MEDLINE search and review of journals was conducted to identify information for this review. DATA SYNTHESIS: Aminoglycosides alone or in combination with beta-lactams are commonly used for their activity against gram-negative microorganisms. Numerous studies have been performed comparing efficacy and toxicity of once-daily administration of aminoglycosides with multiple-daily dosing. Two studies have found a significant difference in clinical efficacy between once-daily and multiple-daily dosing of aminoglycosides. Several studies have observed a lower incidence of toxicity with once-daily than multiple-daily dosing, but others have found no difference. CONCLUSIONS: Review of the literature suggests that once-daily administration of aminoglycosides may be as safe and effective as multiple-daily dosing regimens for the treatment of certain infections caused by gram-negative bacteria.
Authors: A Ahmed; M M París; M Trujillo; S M Hickey; L Wubbel; S L Shelton; G H McCracken Journal: Antimicrob Agents Chemother Date: 1997-01 Impact factor: 5.191
Authors: D Beauchamp; P Collin; L Grenier; M LeBrun; M Couture; L Thibault; G Labrecque; M G Bergeron Journal: Antimicrob Agents Chemother Date: 1996-03 Impact factor: 5.191
Authors: Y Yoshiyama; L Grenier; P Gourde; M Simard; L Lin; N J Morin; M G Bergeron; G Labrecque; D Beauchamp Journal: Antimicrob Agents Chemother Date: 1996-03 Impact factor: 5.191