| Literature DB >> 7910967 |
W W Cruikshank1, D M Center, N Nisar, M Wu, B Natke, A C Theodore, H Kornfeld.
Abstract
Lymphocyte chemoattractant factor (LCF) is a lymphocyte cell product that stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. In concert with its chemoattractant activity, LCF induces human T-lymphocyte expression of interleukin 2 receptor. Here we describe the molecular cloning of cDNA encoding human LCF. It is a novel interleukin with no significant homology to any previously described cytokine families. There is an absolute requirement for both autoaggregation of LCF monomers and for membrane-expressed CD4 molecules for LCF-induced migration in lymphocytes.Entities:
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Year: 1994 PMID： 7910967 PMCID： PMC43941 DOI： 10.1073/pnas.91.11.5109
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205