| Literature DB >> 7910886 |
R A Kuschner1, D G Heppner, S L Andersen, B T Wellde, T Hall, I Schneider, W R Ballou, G Foulds, J C Sadoff, B Schuster.
Abstract
Azithromycin has antimalarial activity and favourable pharmacokinetic properties for a prophylactic antimalarial agent. We investigated the ability of azithromycin to prevent malaria in volunteers infected with a chloroquine-resistant strain of Plasmodium falciparum. 4 volunteers received oral azithromycin 500 mg followed by 250 mg daily for 7 further days. Subjects were infected on the third day of azithromycin. 3 subjects were protected compared with none of 15 controls. The volunteer not protected by azithromycin had unquantifiable plasma levels of azithromycin, probably because of poor absorption. Azithromycin could be a promising prophylactic agent for P falciparum malaria.Entities:
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Year: 1994 PMID： 7910886 DOI： 10.1016/s0140-6736(94)92526-7
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321