| Literature DB >> 7910375 |
S Waga1, B Stillman.
Abstract
Complete enzymatic replication of DNA from the simian virus 40 origin has been reconstituted with T antigen and highly purified cellular proteins. DNA polymerase-alpha/primase functions primarily to synthesize RNA-DNA primers for initiation of DNA replication at the origin and for priming each Okazaki fragment. A polymerase switching mechanism requiring replication factor C and the proliferating cell nuclear antigen allows two molecules of DNA polymerase-delta to replicate both strands of the double helix conjointly.Entities:
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Year: 1994 PMID： 7910375 DOI： 10.1038/369207a0
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962