Literature DB >> 7909987

Linkage of the VNTR/insulin-gene and type I diabetes mellitus: increased gene sharing in affected sibling pairs.

D Owerbach1, K H Gabbay.   

Abstract

Ninety-six multiplex type I diabetic families were typed at the 5' flanking region of the insulin gene by using a PCR assay that better resolves the VNTR into multiple alleles. Affected sibling pairs shared 2, 1, and 0 VNTR alleles--identical by descent--at a frequency of .47, .45, and .08, respectively, a ratio that deviated from the expected 1:2:1 ratio (P < .001). These results confirm linkage of the chromosome 11p15.5 region with type I diabetes mellitus susceptibility.

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Year:  1994        PMID： 7909987      PMCID： PMC1918272     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  20 in total

1.  Assessing the role of HLA-linked and unlinked determinants of disease.

Authors:  N Risch
Journal:  Am J Hum Genet       Date:  1987-01       Impact factor: 11.025

2.  Insulin-dependent diabetes mellitus: a model for the study of multifactorial disorders.

Authors:  L L Field
Journal:  Am J Hum Genet       Date:  1988-12       Impact factor: 11.025

3.  Analysis of a 1963-bp polymorphic region flanking the human insulin gene.

Authors:  D Owerbach; L Aagaard
Journal:  Gene       Date:  1984-12       Impact factor: 3.688

4.  The highly polymorphic region near the human insulin gene is composed of simple tandemly repeating sequences.

Authors:  G I Bell; M J Selby; W J Rutter
Journal:  Nature       Date:  1982-01-07       Impact factor: 49.962

5.  A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus.

Authors:  G I Bell; S Horita; J H Karam
Journal:  Diabetes       Date:  1984-02       Impact factor: 9.461

6.  Measuring the genetic contribution of a single locus to a multilocus disease.

Authors:  J I Rotter; E M Landaw
Journal:  Clin Genet       Date:  1984-12       Impact factor: 4.438

7.  Type I (insulin-dependent) diabetic multiplex families: mode of genetic transmission.

Authors:  A Walker; A G Cudworth
Journal:  Diabetes       Date:  1980-12       Impact factor: 9.461

8.  Insulin gene region-encoded susceptibility to type 1 diabetes is not restricted to HLA-DR4-positive individuals.

Authors:  S C Bain; J B Prins; C M Hearne; N R Rodrigues; B R Rowe; L E Pritchard; R J Ritchie; J R Hall; D E Undlien; K S Ronningen
Journal:  Nat Genet       Date:  1992-11       Impact factor: 38.330

9.  The genetic susceptibility to type 1 (insulin-dependent) diabetes: analysis of the HLA-DR association.

Authors:  E Wolf; K M Spencer; A G Cudworth
Journal:  Diabetologia       Date:  1983-04       Impact factor: 10.122

10.  HLA-D region beta-chain DNA endonuclease fragments differ between HLA-DR identical healthy and insulin-dependent diabetic individuals.

Authors:  D Owerbach; A Lernmark; P Platz; L P Ryder; L Rask; P A Peterson; J Ludvigsson
Journal:  Nature       Date:  1983-06-30       Impact factor: 49.962
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  6 in total

Review 1.  Genetic predisposition to IDDM.

Authors:  S Caillat-Zucman; J F Bach
Journal:  Clin Rev Allergy Immunol       Date:  2000-12       Impact factor: 8.667

2.  Seven regions of the genome show evidence of linkage to type 1 diabetes in a consensus analysis of 767 multiplex families.

Authors:  N J Cox; B Wapelhorst; V A Morrison; L Johnson; L Pinchuk; R S Spielman; J A Todd; P Concannon
Journal:  Am J Hum Genet       Date:  2001-08-15       Impact factor: 11.025

3.  The immunoglobulin heavy-chain variable region in insulin-dependent diabetes mellitus: affected-sib-pair analysis and association studies.

Authors:  R Veijola; M Knip; R Puukka; H Reijonen; D W Cox; J Ilonen
Journal:  Am J Hum Genet       Date:  1996-08       Impact factor: 11.025

4.  Affected-sib-pair mapping of a novel susceptibility gene to insulin-dependent diabetes mellitus (IDDM8) on chromosome 6q25-q27.

Authors:  D F Luo; M M Bui; A Muir; N K Maclaren; G Thomson; J X She
Journal:  Am J Hum Genet       Date:  1995-10       Impact factor: 11.025

5.  IDDM2 and the polymorphism of the human tyrosine hydroxylase (hTH) gene in African Americans with type-1 diabetes.

Authors:  Noureddine Berka; Gail Nunlee-Bland; Elhajja Erabhaoui; Maher Belmamoun; Georgia M Dunston
Journal:  J Natl Med Assoc       Date:  2004-08       Impact factor: 1.798

6.  The insulin polymorphism -23Hph increases the risk for type 1 diabetes mellitus in the Romanian population.

Authors:  Danut Cimponeriu; Pompilia Apostol; Irina Radu; Anne Marie Craciun; Cristian Serafinceanu; Mihai Toma; Cristian Panaite; Dan Cheta
Journal:  Genet Mol Biol       Date:  2010-12-01       Impact factor: 1.771
  6 in total

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