Literature DB >> 6397408

Analysis of a 1963-bp polymorphic region flanking the human insulin gene.

D Owerbach, L Aagaard.   

Abstract

The nucleotide sequence of a long polymorphic region located 365 bp upstream from the human insulin gene is reported. The region is composed of 139 repeating sequences whose consensus structure is related to ACAGGGGTGTGGGG. Expansion in the number of repeating sequences appears to have taken place through duplication and triplication of 112-141-bp regions. However, ancestral polymorphic regions containing additions or deletions of 50 bp or more were not detected in two previous generations.

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Year:  1984        PMID： 6397408     DOI： 10.1016/0378-1119(84)90021-0

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  11 in total

1.  Identification of complex DNA polymorphisms based on variable number of tandem repeats (VNTR) and restriction site polymorphism.

Authors:  J S Waye; R M Fourney
Journal:  Hum Genet       Date:  1990-02       Impact factor: 4.132

2.  Gene probes to detect cross-culture contamination in hormone producing cell lines.

Authors:  I Matsuba; A Lernmark; O Madsen; B Michelsen; J H Nielsen; J Scholler; H Vissing; B Welinder; N Tommerup; M Mikkelsen
Journal:  In Vitro Cell Dev Biol       Date:  1988-11

3.  Assessment of small polymorphisms in defined human collagen gene segments.

Authors:  M Sippola-Thiele; G C Tromp; D J Prockop; F Ramirez
Journal:  Hum Genet       Date:  1986-03       Impact factor: 4.132

4.  Minisatellite isoalleles can be distinguished by single-stranded conformational polymorphism analysis in agarose gels.

Authors:  D G Monckton; A J Jeffreys
Journal:  Nucleic Acids Res       Date:  1994-06-11       Impact factor: 16.971

5.  Tissue-specific expression of transfected human insulin genes in pluripotent clonal rat insulinoma lines induced during passage in vivo.

Authors:  O D Madsen; L C Andersen; B Michelsen; D Owerbach; L I Larsson; A Lernmark; D F Steiner
Journal:  Proc Natl Acad Sci U S A       Date:  1988-09       Impact factor: 11.205

6.  Multiple DNA variant association analysis: application to the insulin gene region in type I diabetes.

Authors:  C Julier; A Lucassen; P Villedieu; M Delepine; C Levy-Marchal; P M Danzé; F Bianchi; C Boitard; P Froguel; J Bell
Journal:  Am J Hum Genet       Date:  1994-12       Impact factor: 11.025

Review 7.  Insulin-gene flanking sequences, diabetes mellitus and atherosclerosis: a review.

Authors:  T Mandrup-Poulsen; D Owerbach; J Nerup; K Johansen; J Ingerslev; A T Hansen
Journal:  Diabetologia       Date:  1985-08       Impact factor: 10.122

8.  Human tyrosine hydroxylase and insulin genes are contiguous on chromosome 11.

Authors:  K L O'Malley; P Rotwein
Journal:  Nucleic Acids Res       Date:  1988-05-25       Impact factor: 16.971

9.  Diabetes mellitus, atherosclerosis, and the 5' flanking polymorphism of the human insulin gene.

Authors:  T Mandrup-Poulsen; D Owerbach; J Nerup; K Johansen; A Tybjaerg Hansen
Journal:  J Inherit Metab Dis       Date:  1986       Impact factor: 4.982

10.  Linkage of the VNTR/insulin-gene and type I diabetes mellitus: increased gene sharing in affected sibling pairs.

Authors:  D Owerbach; K H Gabbay
Journal:  Am J Hum Genet       Date:  1994-05       Impact factor: 11.025
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