| Literature DB >> 7908145 |
J F Fallon1, A López, M A Ros, M P Savage, B B Olwin, B K Simandl.
Abstract
The apical ectodermal ridge permits growth and elongation of amniote limb buds; removal causes rapid changes in mesodermal gene expression, patterned cell death, and truncation of the limb. Ectopic fibroblast growth factor (FGF)-2 supplied to the chick apical bud mesoderm after ridge removal will sustain normal gene expression and cell viability, and allow relatively normal limb development. A bioassay for FGFs demonstrated that FGF-2 was the only detectable FGF in chick limb bud extracts. By distribution and bioactivity, FGF-2 is the prime candidate for the chick limb bud apical ridge growth signal.Entities:
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Year: 1994 PMID： 7908145 DOI： 10.1126/science.7908145
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728