Literature DB >> 7908027

Alterations of brain metabolites in metachromatic leukodystrophy as detected by localized proton magnetic resonance spectroscopy in vivo.

B Kruse1, F Hanefeld, H J Christen, H Bruhn, T Michaelis, W Hänicke, J Frahm.   

Abstract

The brain morphology and chemistry of seven children with late infantile (4/7) and juvenile (3/7) forms of metachromatic leukodystrophy (MLD) were investigated by magnetic resonance imaging (MRI) and localized proton magnetic resonance spectroscopy (MRS). Patients who were examined at least 6 months after the onset of symptoms (6/7) had severe leukodystrophic changes on MRI. Proton MRS revealed a marked reduction of the neuronal marker N-acetylaspartate in white and grey matter and elevated lactate in demyelinated areas. In contrast to other leukodystrophies MLD patients showed a generalized increase of brain myo-inositol (2- to 3-fold in white matter), indicating a specific role in the pathophysiology of demyelination in MLD.

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Year:  1993        PMID： 7908027     DOI： 10.1007/bf00869766

Source DB:  PubMed          Journal:  J Neurol        ISSN： 0340-5354            Impact factor:   4.849


  21 in total

1.  Bone marrow transplantation for metabolic diseases with severe neurological symptoms.

Authors:  P M Hoogerbrugge; O F Brouwer; A Fischer
Journal:  Bone Marrow Transplant       Date:  1991       Impact factor: 5.483

2.  Treatment of late infantile metachromatic leukodystrophy by bone marrow transplantation.

Authors:  W Krivit; E Shapiro; W Kennedy; M Lipton; L Lockman; S Smith; C G Summers; D A Wenger; M Y Tsai; N K Ramsay
Journal:  N Engl J Med       Date:  1990-01-04       Impact factor: 91.245

3.  Proton NMR spectroscopy of cerebral metabolic alterations in infantile peroxisomal disorders.

Authors:  H Bruhn; B Kruse; G C Korenke; F Hanefeld; W Hänicke; K D Merboldt; J Frahm
Journal:  J Comput Assist Tomogr       Date:  1992 May-Jun       Impact factor: 1.826

Review 4.  Metabolism and function of myo-inositol and inositol phospholipids.

Authors:  B J Holub
Journal:  Annu Rev Nutr       Date:  1986       Impact factor: 11.848

5.  Age-dependent changes in localized proton and phosphorus MR spectroscopy of the brain.

Authors:  M S van der Knaap; J van der Grond; P C van Rijen; J A Faber; J Valk; K Willemse
Journal:  Radiology       Date:  1990-08       Impact factor: 11.105

6.  Multiple sclerosis in children: cerebral metabolic alterations monitored by localized proton magnetic resonance spectroscopy in vivo.

Authors:  H Bruhn; J Frahm; K D Merboldt; W Hänicke; F Hanefeld; H J Christen; B Kruse; H J Bauer
Journal:  Ann Neurol       Date:  1992-08       Impact factor: 10.422

7.  Metabolic disorders of the brain in chronic hepatic encephalopathy detected with H-1 MR spectroscopy.

Authors:  R Kreis; B D Ross; N A Farrow; Z Ackerman
Journal:  Radiology       Date:  1992-01       Impact factor: 11.105

8.  Biochemical studies of metachromatic leukodystrophy in three siblings.

Authors:  W T Norton; S E Poduslo
Journal:  Acta Neuropathol       Date:  1982       Impact factor: 17.088

9.  Longitudinal neurophysiologic studies in a patient with metachromatic leukodystrophy following bone marrow transplantation.

Authors:  A Dhuna; C Toro; F Torres; W R Kennedy; W Krivit
Journal:  Arch Neurol       Date:  1992-10

10.  Multiple sclerosis in childhood: report of 15 cases.

Authors:  F Hanefeld; H J Bauer; H J Christen; B Kruse; H Bruhn; J Frahm
Journal:  Brain Dev       Date:  1991-11       Impact factor: 1.961
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  20 in total

Review 1.  MR spectroscopy and spectroscopic imaging of the brain.

Authors:  He Zhu; Peter B Barker
Journal:  Methods Mol Biol       Date:  2011

2.  Biochemical changes in the frontal lobe of HIV-infected individuals detected by magnetic resonance spectroscopy.

Authors:  D López-Villegas; R E Lenkinski; I Frank
Journal:  Proc Natl Acad Sci U S A       Date:  1997-09-02       Impact factor: 11.205

3.  Toward a better understanding of brain lesions during metachromatic leukodystrophy evolution.

Authors:  A Martin; C Sevin; C Lazarus; C Bellesme; P Aubourg; C Adamsbaum
Journal:  AJNR Am J Neuroradiol       Date:  2012-04-26       Impact factor: 3.825

Review 4.  Recent advances in magnetic resonance neurospectroscopy.

Authors:  Yael Rosen; Robert E Lenkinski
Journal:  Neurotherapeutics       Date:  2007-07       Impact factor: 7.620

Review 5.  Inborn errors of metabolism for the diagnostic radiologist.

Authors:  Chris J Hendriksz
Journal:  Pediatr Radiol       Date:  2008-12-13

Review 6.  Leukoencephalopathies and metabolic diseases.

Authors:  Antonio Giorgio; Nicola De Stefano
Journal:  Neurol Sci       Date:  2008-10       Impact factor: 3.307

7.  Diagnostic and prognostic value of in vivo proton MR spectroscopy for Zellweger syndrome spectrum patients.

Authors:  H Rosewich; P Dechent; C Krause; A Ohlenbusch; K Brockmann; J Gärtner
Journal:  J Inherit Metab Dis       Date:  2016-08-03       Impact factor: 4.982

Review 8.  Proton magnetic resonance spectroscopy in brain white matter disorders.

Authors:  N De Stefano; A Federico; D L Arnold
Journal:  Ital J Neurol Sci       Date:  1997-12

9.  Region- and age-dependent alterations of glial-neuronal metabolic interactions correlate with CNS pathology in a mouse model of globoid cell leukodystrophy.

Authors:  Tore Wergeland Meisingset; Alessandra Ricca; Margherita Neri; Ursula Sonnewald; Angela Gritti
Journal:  J Cereb Blood Flow Metab       Date:  2013-04-24       Impact factor: 6.200

10.  Unraveling pathology in juvenile Alexander disease: serial quantitative MR imaging and spectroscopy of white matter.

Authors:  J Patrick van der Voorn; Petra J W Pouwels; Gajja S Salomons; Frederik Barkhof; Marjo S van der Knaap
Journal:  Neuroradiology       Date:  2009-05-30       Impact factor: 2.804
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