Literature DB >> 7905740

A role for a pre-T-cell receptor in T-cell development.

M Groettrup1, H von Boehmer.   

Abstract

Expression of a productive T-cell receptor (TCR) beta gene has profound consequences for T-cell development, preceding an increase in thymocyte number, appearance of CD4 and CD8 coreceptors and suppression of further TCR beta-gene rearrangement. Here Marcus Groettrup and Harald von Boehmer discuss the data obtained in various experimental models and describe a novel signal transducing receptor complex on pre-T cells, which may regulate the TCR beta-induced developmental changes.

Entities:  

Mesh：

Substances：

Year:  1993        PMID： 7905740     DOI： 10.1016/0167-5699(93)90201-U

Source DB:  PubMed          Journal:  Immunol Today        ISSN： 0167-5699


  21 in total

1.  Nucleoprotein structure of the CD4 locus: implications for the mechanisms underlying CD4 regulation during T cell development.

Authors:  Ming Yu; Mimi Wan; Jianmin Zhang; Jie Wu; Rohini Khatri; Tian Chi
Journal:  Proc Natl Acad Sci U S A       Date:  2008-03-05       Impact factor: 11.205

Review 2.  Towards a molecular understanding of the differential signals regulating alphabeta/gammadelta T lineage choice.

Authors:  Sang-Yun Lee; Jason Stadanlick; Dietmar J Kappes; David L Wiest
Journal:  Semin Immunol       Date:  2010-05-14       Impact factor: 11.130

3.  Activated Ras signals differentiation and expansion of CD4+8+ thymocytes.

Authors:  W Swat; Y Shinkai; H L Cheng; L Davidson; F W Alt
Journal:  Proc Natl Acad Sci U S A       Date:  1996-05-14       Impact factor: 11.205

4.  Regulation of AP-1 and NFAT transcription factors during thymic selection of T cells.

Authors:  M Rincon; R A Flavell
Journal:  Mol Cell Biol       Date:  1996-03       Impact factor: 4.272

5.  Interferons alpha/beta inhibit IL-7-induced proliferation of CD4- CD8- CD3- CD44+ CD25+ thymocytes, but do not inhibit that of CD4- CD8- CD3- CD44- CD25- thymocytes.

Authors:  D M Su; J Wang; Q Lin; M D Cooper; T Watanabe
Journal:  Immunology       Date:  1997-04       Impact factor: 7.397

6.  Subunit composition of the pre-T-cell receptor complex analysed by monoclonal antibody against the pre-T-cell receptor alpha chain.

Authors:  A Kosugi; S Noda; S Saitoh; S Narumiya; M Ogata; Y Hashimoto; K Takase; T Saito; T Hamaoka
Journal:  Immunology       Date:  1997-08       Impact factor: 7.397

7.  Regulation of T-cell antigen receptor (TCR) alpha-chain expression by TCR beta-chain transcripts.

Authors:  S Chung; J L Strominger
Journal:  Proc Natl Acad Sci U S A       Date:  1995-04-25       Impact factor: 11.205

8.  Block of T lymphocyte differentiation by activation of the cAMP-dependent signal transduction pathway.

Authors:  E Lalli; P Sassone-Corsi; R Ceredig
Journal:  EMBO J       Date:  1996-02-01       Impact factor: 11.598

9.  Evidence implicating Gfi-1 and Pim-1 in pre-T-cell differentiation steps associated with beta-selection.

Authors:  T Schmidt; H Karsunky; B Rödel; B Zevnik; H P Elsässer; T Möröy
Journal:  EMBO J       Date:  1998-09-15       Impact factor: 11.598

10.  Cross-lineage expression of Ig-beta (B29) in thymocytes: positive and negative gene regulation to establish T cell identity.

Authors:  H Wang; R A Diamond; E V Rothenberg
Journal:  Proc Natl Acad Sci U S A       Date:  1998-06-09       Impact factor: 11.205
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.