Literature DB >> 7896773

Inhibition of mitochondrial ATPase by dicarbopolyborate, a new enzyme inhibitor.

Z Drahota1, V Mares, H Rauchová, P Saf, M Kalous.   

Abstract

Polyborate anions were found to inhibit mitochondrial ATPase. Mercapto and chloro derivatives of dicarbononaborates showed full inhibition of the enzyme activity at 0.5-0.8 mM. The inhibitory effect of dodecaborates was lower. The inhibition was of competitive type with respect to ATP. The inhibition of soluble F1-ATPase indicates a direct interaction of the polyborate anion with the catalytic part of the enzyme molecule.

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Year:  1994        PMID： 7896773     DOI： 10.1007/bf00762743

Source DB:  PubMed          Journal:  J Bioenerg Biomembr        ISSN： 0145-479X            Impact factor:   2.945


  11 in total

1.  Determination of organic phosphorus compounds by phosphate analysis.

Authors:  L ERNSTER; O LINDBERG
Journal:  Methods Biochem Anal       Date:  1956

2.  Membrane lateral pressure as a modulator of glycerol-3-phosphate dehydrogenase activity.

Authors:  E Amler; R Jasińska; Z Drahota; J Zborowski
Journal:  FEBS Lett       Date:  1990-10-01       Impact factor: 4.124

3.  Regulation of glycerol 3-phosphate oxidation in mitochondria by changes in membrane microviscosity.

Authors:  E Amler; H Rauchová; J Svobodová; Z Drahota
Journal:  FEBS Lett       Date:  1986-09-29       Impact factor: 4.124

4.  Membrane potential generation by two reconstituted mitochondrial systems: liposomes inlayed with cytochrome oxidase or with ATPase.

Authors:  A A Jasàitis; I B Nemecek; I I Severina; V P Skulachev; S M Smirnova
Journal:  Biochim Biophys Acta       Date:  1972-09-20

5.  Studies of the energy-transfer system of submitochondrial particles. 2. Effects of oligomycin and aurovertin.

Authors:  C Lee; L Ernster
Journal:  Eur J Biochem       Date:  1968-02

6.  Conversion of biomembrane-produced energy into electric form. II. Intact mitochondria.

Authors:  L E Bakeeva; L L Grinius; A A Jasaitis; V V Kuliene; D O Levitsky; E A Liberman; I I Severina; V P Skulachev
Journal:  Biochim Biophys Acta       Date:  1970-08-04

7.  Accumulation of a slow neutron capturing substance, mercaptoundecahydrododecaborate (MHB), in cell cultures and biological monitoring of the 10B(nth, alpha)7 Li reaction.

Authors:  V Mares; J Burián; M Baudysová; J Kvítek; V Hnatovicz; J Cervená; J Vacík; J Folbergrová
Journal:  Eur J Histochem       Date:  1992       Impact factor: 3.188

8.  Stabilization of rat liver mitochondrial F1-adenosine triphosphatase during chloroform-induced solubilization.

Authors:  J Kopecký; S Kuzela; J Kraml; Z Drahota
Journal:  Biochim Biophys Acta       Date:  1979-08-14

9.  Accumulation of boron-10 (10B) in cell cultures exposed to mercaptododecaborate (Na2H(11)10B12SH) used for the neutron capture therapy of brain tumors.

Authors:  V Mares; M Baudysová; J Kvítek; V Hnatovicz; J Cervená; J Vacík; J Folbergrová
Journal:  J Pharmacol Exp Ther       Date:  1992-08       Impact factor: 4.030

10.  An electron-transport system associated with the outer membrane of liver mitochondria. A biochemical and morphological study.

Authors:  G L Sottocasa; B Kuylenstierna; L Ernster; A Bergstrand
Journal:  J Cell Biol       Date:  1967-02       Impact factor: 10.539
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  2 in total

Review 1.  ATP synthase and the actions of inhibitors utilized to study its roles in human health, disease, and other scientific areas.

Authors:  Sangjin Hong; Peter L Pedersen
Journal:  Microbiol Mol Biol Rev       Date:  2008-12       Impact factor: 11.056

2.  Novel inhibitors of mitochondrial sn-glycerol 3-phosphate dehydrogenase.

Authors:  Adam L Orr; Deepthi Ashok; Melissa R Sarantos; Ryan Ng; Tong Shi; Akos A Gerencser; Robert E Hughes; Martin D Brand
Journal:  PLoS One       Date:  2014-02-24       Impact factor: 3.240
  2 in total

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