PURPOSE: To evaluate the accuracy and limitations of magnetic resonance (MR) angiographic screening for incidental intracranial aneurysms (IAs) in healthy individuals with a family history of IA. MATERIALS AND METHODS: Four hundred asymptomatic individuals in 68 families with a history of aneurysmal subarachnoid hemorrhage underwent MR angiography. Six families also had a history of polycystic kidney disease. A multislab, three-dimensional, time-of-flight sequence was used. Conventional angiography was performed to confirm positive MR angiographic findings. RESULTS: IAs were detected with MR angiography in 37 individuals, 32 of whom underwent conventional angiography. Intraobserver consistency was excellent (kappa = 0.96), and interobserver reproducibility was good to excellent (kappa = 0.59-0.82). Both techniques showed similar results in the evaluation of size, localization, and orientation of aneurysms and visibility of the aneurysm neck. CONCLUSION: MR angiography is an accurate and feasible method of noninvasive screening for IAs in individuals at high risk. Conventional angiography is still necessary before operative treatment.
PURPOSE: To evaluate the accuracy and limitations of magnetic resonance (MR) angiographic screening for incidental intracranial aneurysms (IAs) in healthy individuals with a family history of IA. MATERIALS AND METHODS: Four hundred asymptomatic individuals in 68 families with a history of aneurysmal subarachnoid hemorrhage underwent MR angiography. Six families also had a history of polycystic kidney disease. A multislab, three-dimensional, time-of-flight sequence was used. Conventional angiography was performed to confirm positive MR angiographic findings. RESULTS: IAs were detected with MR angiography in 37 individuals, 32 of whom underwent conventional angiography. Intraobserver consistency was excellent (kappa = 0.96), and interobserver reproducibility was good to excellent (kappa = 0.59-0.82). Both techniques showed similar results in the evaluation of size, localization, and orientation of aneurysms and visibility of the aneurysm neck. CONCLUSION: MR angiography is an accurate and feasible method of noninvasive screening for IAs in individuals at high risk. Conventional angiography is still necessary before operative treatment.
Authors: Manraj K S Heran; Francis Marshalleck; Michael Temple; Clement J Grassi; Bairbre Connolly; Richard B Towbin; Kevin M Baskin; Josee Dubois; Mark J Hogan; Sanjoy Kundu; Donald L Miller; Derek J Roebuck; Steven C Rose; David Sacks; Manrita Sidhu; Michael J Wallace; Darryl A Zuckerman; John F Cardella Journal: Pediatr Radiol Date: 2010-02
Authors: S W Park; M H Han; S H Cha; B J Kwon; K H Kim; O K Kwon; S K Baik; K H Chang Journal: Interv Neuroradiol Date: 2004-10-20 Impact factor: 1.610
Authors: C H Castaño-Duque; J Ruscalleda-Nadal; M de Juan-Delago; E Guardia-Mas; L San Roman-Manzanera; F Bartomeus-Jene; J Molet-Teixido; P Tresserras-Ribo; P Pares-Muñoz; P Clavel Laria Journal: Interv Neuroradiol Date: 2004-10-20 Impact factor: 1.610
Authors: Jane M Olson; Sompong Vongpunsawad; Helena Kuivaniemi; Antti Ronkainen; Juha Hernesniemi; Markku Ryynänen; Lee-Lian Kim; Gerard Tromp Journal: BMC Med Genet Date: 2002-08-01 Impact factor: 2.103