Literature DB >> 7889967

Activity of the fourth generation cephalosporin FK-037 against methicillin-resistant Staphylococcus aureus under conditions maximizing PBP2' production.

J M Hamilton-Miller1.   

Abstract

To investigate the in vitro activity of the fourth generation cephalosporin FK-037, MICs were determined for 80 strains of methicillin-resistant Staphylococcus aureus from 11 countries. Methicillin and cefamandole served as comparators. The method ensured good expression of PBP2' by use of a large inoculum, salt supplement and incubation for 48 hours at 30 degrees C. FK-037 was twice as active as cefamandole against both strains with high-level and strains with low-level methicillin resistance (geometric mean MICs 23.4 and 10.8 mg/l, respectively).

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Year:  1994        PMID： 7889967     DOI： 10.1007/bf02111826

Source DB:  PubMed          Journal:  Eur J Clin Microbiol Infect Dis        ISSN： 0934-9723            Impact factor:   3.267


  11 in total

1.  In vitro and in vivo activities of DQ-2556 and its mode of action.

Authors:  M Tanaka; M Otsuki; T Nishino
Journal:  Antimicrob Agents Chemother       Date:  1992-12       Impact factor: 5.191

Review 2.  Methicillin-resistant Staphylococcus aureus.

Authors:  W Brumfitt; J Hamilton-Miller
Journal:  N Engl J Med       Date:  1989-05-04       Impact factor: 91.245

3.  Antibiogram typing of methicillin-resistant Staphylococcus aureus: a comparison with phage typing, biotyping and API Staph.

Authors:  J M Hamilton-Miller; P A Maple
Journal:  Zentralbl Bakteriol       Date:  1993-06

4.  Effects of culture media on detection of methicillin resistance in Staphylococcus aureus and coagulase negative staphylococci by disc diffusion methods.

Authors:  L M Milne; M R Crow; A G Emptage; J B Selkon
Journal:  J Clin Pathol       Date:  1993-05       Impact factor: 3.411

5.  Activity of beta-lactam antibiotics in an animal model against methicillin-resistant Staphylococcus aureus.

Authors:  J M Ling; A W Lam; A F Cheng; G L French
Journal:  J Antimicrob Chemother       Date:  1993-12       Impact factor: 5.790

6.  Multicenter comparison of in vitro activities of FK-037, cefepime, ceftriaxone, ceftazidime, and cefuroxime.

Authors:  J A Washington; R N Jones; E H Gerlach; P R Murray; S D Allen; C C Knapp
Journal:  Antimicrob Agents Chemother       Date:  1993-08       Impact factor: 5.191

7.  In vitro activity and beta-lactamase stability of FK-037, a parenteral cephalosporin.

Authors:  H C Neu; N X Chin; H B Huang
Journal:  Antimicrob Agents Chemother       Date:  1993-03       Impact factor: 5.191

8.  In vitro and in vivo antibacterial activities of E1077, a novel parenteral cephalosporin.

Authors:  T Toyosawa; S Miyazaki; A Tsuji; K Yamaguchi; S Goto
Journal:  Antimicrob Agents Chemother       Date:  1993-01       Impact factor: 5.191

9.  Excellent activity of FK037, a novel parenteral broad-spectrum cephalosporin, against methicillin-resistant staphylococci.

Authors:  Y Mine; Y Watanabe; H Sakamoto; K Hatano; K Kuno; T Kamimura; S Tawara; Y Matsumoto; F Matsumoto; S Kuwahara
Journal:  J Antibiot (Tokyo)       Date:  1993-01       Impact factor: 2.649

10.  In vitro and in vivo activities of SCE-2787, a new parenteral cephalosporin with a broad antibacterial spectrum.

Authors:  T Iwahi; K Okonogi; T Yamazaki; S Shiki; M Kondo; A Miyake; A Imada
Journal:  Antimicrob Agents Chemother       Date:  1992-07       Impact factor: 5.191
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