Literature DB >> 788651

Detection of circulating IgG aggregates and immune complexes using 125I protein A from Staphylococcus aureus.

R Hällgren, L Wide.   

Abstract

A method for detection of circulating immune complexes by the use of 125I labelled staphylococcal protein A is described. In a polyethylene glycol solution as little as 1-2 mg/l of soluble heat aggregated human IgG could be quantitated. Variables which might influence the assay were examined. Separation of immune complexes in serum from monomeric IgG was essential and achieved by gel chromatography on Sephadex G200. This assay may be suitable for clinical routine for detection and quantitation of immune complexes. A preliminary study on the clinical application of the method is presented. 58% of patients with systemic lupus erythematosus and 42% of patients with rheumatoid arthritis had increased levels of immune aggregates in serum compared to a group of healthy individuals.

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Year:  1976        PMID： 788651      PMCID： PMC1007387          DOI： 10.1136/ard.35.4.306

Source DB:  PubMed          Journal:  Ann Rheum Dis        ISSN： 0003-4967            Impact factor:   19.103


  28 in total

1.  THE INTERACTION BETWEEN POLYSACCHARIDES AND OTHER MACROMOLECULES. 4. THE OSMOTIC PRESSURE OF MIXTURES OF SERUM ALBUMIN AND HYALURONIC ACID.

Authors:  T C LAURENT; A G OGSTON
Journal:  Biochem J       Date:  1963-11       Impact factor: 3.857

2.  Gamma globulin complexes in rheumatoid arthritis and certain other conditions.

Authors:  H G KUNKEL; H J MULLER-EBERHARD; H H FUDENBERG; T B TOMASI
Journal:  J Clin Invest       Date:  1961-01       Impact factor: 14.808

3.  Some immunological studies of the nephrotic syndrome of Nigerian children.

Authors:  J F Soothill; R G Hendrickse
Journal:  Lancet       Date:  1967-09-23       Impact factor: 79.321

4.  "Protein A" from S. aureus. I. Pseudo-immune reaction with human gamma-globulin.

Authors:  A Forsgren; J Sjöquist
Journal:  J Immunol       Date:  1966-12       Impact factor: 5.422

5.  IgG complexes in serum of rheumatoid arthritis patients.

Authors:  R Norberg
Journal:  Scand J Immunol       Date:  1974       Impact factor: 3.487

6.  Evidence for complement-binding immune complexes in adult coeliac disease, Crohn's disease, and ulcerative colitis.

Authors:  W F Doe; C C Booth; D L Brown
Journal:  Lancet       Date:  1973-02-24       Impact factor: 79.321

7.  Circulating immune complexes in dermatitis herpetiformis.

Authors:  J F Mowbray; A V Hoffbrand; E J Holborow; P P Seah; L Fry
Journal:  Lancet       Date:  1973-02-24       Impact factor: 79.321

8.  Ultrastructure of the human complement component, Clq (negative staining-glutamine synthetase-biologically active Clq).

Authors:  E Shelton; K Yonemasu; R M Stroud
Journal:  Proc Natl Acad Sci U S A       Date:  1972-01       Impact factor: 11.205

9.  Characterization of the gamma-globulin complexes present in certain sera having high titers of anti-gamma-globulin activity.

Authors:  R E Schrohenloher
Journal:  J Clin Invest       Date:  1966-04       Impact factor: 14.808

10.  Serial complement component alterations in acute glomerulonephritis and systemic lupus erythematosus.

Authors:  P F Kohler; R Ten Bensel
Journal:  Clin Exp Immunol       Date:  1969-02       Impact factor: 4.330
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  11 in total

1.  Human serum inhibits the interaction between C1q or rheumatoid factor and IgG-coated latex particles. Reduction of these C1-dependent properties after complement activation in vitro and in vivo.

Authors:  R Hällgren
Journal:  Immunology       Date:  1979-11       Impact factor: 7.397

Review 2.  Immune complexes in human diseases: a review.

Authors:  A N Theofilopoulos; F J Dixon
Journal:  Am J Pathol       Date:  1980-08       Impact factor: 4.307

3.  Immune adherence and staphylococcus protein A binding of soluble immune complexes produced by complement activation.

Authors:  J A Schifferli; D K Peters
Journal:  Clin Exp Immunol       Date:  1983-12       Impact factor: 4.330

4.  Predominance of immunoglobulin G sub-class 3 among the complement-fixing antibodies to streptococcal M-associated protein.

Authors:  G E Mortimer; J P Widdowson
Journal:  Clin Exp Immunol       Date:  1979-08       Impact factor: 4.330

5.  Quantitation and characterization of soluble immune complexes precipitated from sera by polyethylene glycol (PEG).

Authors:  D Chia; E V Barnett; J Yamagata; D Knutson; C Restivo; D Furst
Journal:  Clin Exp Immunol       Date:  1979-09       Impact factor: 4.330

6.  Precipitation of 125I-labelled IgG aggregates by factors in sera of healthy individuals and of patients with rheumatoid arthritis.

Authors:  R Hällgren; L Wide
Journal:  Ann Rheum Dis       Date:  1977-02       Impact factor: 19.103

7.  Immune complexes in peripheral blood polymorphonuclear leucocytes of patients with Raynaud's phenomenon.

Authors:  J van der Maulen; A A Wouda; E Mandema; T H The
Journal:  Clin Exp Immunol       Date:  1979-01       Impact factor: 4.330

8.  Reduced opsonisation of protein A containing Staphylococcus aureus in sera with cryoglobulins from patients with active systemic lupus erythematosus.

Authors:  O Nived; C Linder; H Odeberg; B Svensson
Journal:  Ann Rheum Dis       Date:  1985-04       Impact factor: 19.103

9.  Binding of immunoglobulin G aggregates and immune complexes in human sera to Staphylococci containing protein A.

Authors:  J S McDougal; P B Redecha; R D Inman; C L Christian
Journal:  J Clin Invest       Date:  1979-04       Impact factor: 14.808

10.  Circulating immune complexes in patients with diabetes mellitus.

Authors:  C K Abrass; D Heber; J Lieberman
Journal:  Clin Exp Immunol       Date:  1983-04       Impact factor: 4.330
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