Literature DB >> 7880746

Level of expression of E-cadherin mRNA in colorectal cancer correlates with clinical outcome.

S Dorudi1, A M Hanby, R Poulsom, J Northover, I R Hart.   

Abstract

A series of colorectal carcinomas (n = 49) resected from patients with known clinical outcomes were analysed for E-cadherin expression using in situ hybridisation to measure mRNA. Patients surviving 5 years or longer (n = 31) exhibited significantly higher levels of E-cadherin mRNA than those surviving less than 5 years (n = 18, P = 0.003). These preliminary results from this small sample suggest that E-cadherin expression may be a useful prognostic marker in colorectal cancer patients.

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Year:  1995        PMID： 7880746      PMCID： PMC2033614          DOI： 10.1038/bjc.1995.119

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  17 in total

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Journal:  Annu Rev Biochem       Date:  1990       Impact factor: 23.643

5.  E-cadherin expression in colorectal cancer. An immunocytochemical and in situ hybridization study.

Authors:  S Dorudi; J P Sheffield; R Poulsom; J M Northover; I R Hart
Journal:  Am J Pathol       Date:  1993-04       Impact factor: 4.307

6.  Human actin genes are single copy for alpha-skeletal and alpha-cardiac actin but multicopy for beta- and gamma-cytoskeletal genes: 3' untranslated regions are isotype specific but are conserved in evolution.

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Journal:  Ann R Coll Surg Engl       Date:  1994-01       Impact factor: 1.891

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  35 in total

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Journal:  Oncogene       Date:  2008-09-22       Impact factor: 9.867

Review 6.  Tissue-based biomarkers predicting outcomes in metastatic colorectal cancer: a review.

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7.  Downregulation of E-cadherin in the reparative epithelium of the human gastrointestinal tract.

Authors:  A M Hanby; R Chinery; R Poulsom; R J Playford; M Pignatelli
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8.  Severe neonatal anemia increases intestinal permeability by disrupting epithelial adherens junctions.

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9.  Positive expression of LSD1 and negative expression of E-cadherin correlate with metastasis and poor prognosis of colon cancer.

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10.  Effects of carbon dioxide and nitrogen on adhesive growth and expressions of E-cadherin and VEGF of human colon cancer cell CCL-228.

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